| Tag | Content |
|---|
EnhancerAtlas ID | HS139-20298 |
Organism | Homo sapiens |
Tissue/cell | Myotube |
Coordinate | chr16:11145500-11154750 |
SNPs | | Number: 1 | ID | Chromosome | Position | Genome Version |
|
TF binding sites/motifs | | TF | JASPAR ID | Coordinate | Motif Sequence | Strand | -Log10(p-value) |
| BCL6 | MA0463.2 | chr16:11146109-11146125 | CTTTCTTAGAAAGCAC | - | 6.35 | | BHLHE40 | MA0464.2 | chr16:11151284-11151294 | GTCACGTGAT | - | 6.02 | | CDX2 | MA0465.1 | chr16:11151870-11151881 | TTTTATGGCTC | - | 6.14 | | GLI2 | MA0734.2 | chr16:11152824-11152839 | TGACCACCCACGTCT | + | 6.14 | | INSM1 | MA0155.1 | chr16:11145637-11145649 | TGCCCCCAGGCA | - | 6.04 | | IRF1 | MA0050.2 | chr16:11148779-11148800 | GTTTTCTTTCTTTTTTTTTTT | + | 6.33 | | RREB1 | MA0073.1 | chr16:11151846-11151866 | TTGTTTTGGGTGTGGTGGGG | - | 6.01 | | STAT1 | MA0137.3 | chr16:11146133-11146144 | TTTCCTAGAAA | - | 6.14 | | Stat4 | MA0518.1 | chr16:11146130-11146144 | CCTTTTCCTAGAAA | - | 6.34 | | TFEB | MA0692.1 | chr16:11151284-11151294 | GTCACGTGAT | - | 6.02 |
|
| | Number of super-enhancer constituents: 4 | ID | Coordinate | Tissue/cell |
| SE_25367 | chr16:11143021-11151686 | DND41 | | SE_25367 | chr16:11152544-11155160 | DND41 | | SE_33447 | chr16:11145897-11153444 | H2171 | | SE_67024 | chr16:11145897-11153444 | H2171 |
|
| | Diseases: AD,Huntington,Obesity,Parkinson,Prostate cancer,Schizophrenia and Sleep disorder | | Number of disease enhancers: 1 | Chromosome | Start | End |
|
| | Number: 4 | ID | Chromosome | Start | End |
| GH16I011057 | chr16 | 11151003 | 11152374 | | GH16I011058 | chr16 | 11152533 | 11153393 | | GH16I011059 | chr16 | 11153578 | 11153681 | | GH16I011045 | chr16 | 11139384 | 11147133 |
|
Enhancer Sequence | GAGTGAGCAC AGGACCTGTC ATCTCCTGGG CCACTGTTCT CCAGAACCAC TCCCAGACCA 60
GGGAGGAAAG GGCTTCTTTG TCAAAGTCAA GAGCCTGCCC TCAACACAGC TTAGACAGTG 120
GATAGAGAGT ACCCATTTGC CCCCAGGCAT GACTTTCCAA GGCATGTTTT TACCCTTTGG 180
GAAGTAGGGT TTGGCATTCC GTTGCATCTG GCACCCAGTG TTGGCTGCAG AGAGGTAGCC 240
TTCACCAGTG CAGACAGACA AGCCCTGAGC TCAGGAGTGT AAGGCAATGG GGCCAGTTTT 300
CTGTGAACCA TCGGGGGTGA GCACGGTACA TCCAGTGCAG GTGAGGTTGG TGTGAAATCG 360
TAGCCCAGCG GTCTCAGGAC CCCCAGAGAT AGTGCGATGT TAAGGCATCT ACCTGCTCTT 420
GGGACACAGT CAAATTAAAT GTGAATCTCA CCAGCCTGCA GGACAGATAT GTGTGAAAAG 480
ATTAGTTCTC AGAACCAGCT GCAGTGTGTG CTTCCGTTAT CAGCCCTTTT TTTCCGAAGC 540
AGGTACTCTA GGAAGCAGTG TCCTCAGGGG TGTTCATGGT ATTTTATCTC CCGGGTAAGA 600
TCAGAGTTTC TTTCTTAGAA AGCACCATCA CCTTTTCCTA GAAAATCATT CACTGGAGAC 660
ATGAGTATTT GTGTATAGTT CAGAGGAATT CATTGCACAC AGCTCCCCTT GTCAGCCTTT 720
ATCATCTGAG TTAATTCGTG TGTGACAGAG GTGTTTCACT TTTGGATTTT GCAAAACAGG 780
AATGACCTGT CATTTGCACC TCAGACACGA GGAGTCTGAA CCTTCCTCCC TGCAGCTGGT 840
GGTTCTACCT CGGAAGCCTG GGGGTGCAGA GGAAGTGGGA CCCATGTGTC TTGAGTCAAT 900
CCACATTTCC AACTGTCTGA CCAAACCCAC AAGCCTCACC GCAGGACCCA CCCTGTCCGG 960
CCCACTGACG CCTTCCTTCC ATGTCCTCCC TGCCAGGCAC ACGATTCTGT TTGTGGGTGG 1020
CAGTGTTTGC ACTGGACGTC CTGGCATCAG CTTTCACTGG AGGACTGGTT CTGACAGATG 1080
TGTATGTGTT GCTTCATGAT GCTGACGTGC TCACCCCCAG CCAGGGCTAC AGCATCCTGT 1140
GCCAAGAAGG CCCCACCTGG GAGATCCCCC CGCACCCCTG AGCCAGAAGG TCCAGAGGAC 1200
TGAACGCTGA GCACTGCTGC TCTGGATTCC ACTTTGCCTT TTTGTTGTTG TTGTTGTTGT 1260
TGTTGTTTTG GAGGCTGCAG TGAGCTGTGA TCCATCCTGG AGTGCAGTGT TGCGATCATA 1320
GCTCACTGCA GCCTCAAACT CCTGGGCTCC AGCCATCCTC CCACCTCAGC GTCGGTAGCT 1380
GGAACTACAG GCACAAGCTA CCACACCTAG CTAATTTTTA GATGTTTTAT AGAGATGAAG 1440
TCTTGCTAAG TTACCCAAGT TAGCCTTGAA CTCCTGGCCT CAAGCCATCC TCCTGCCTTG 1500
GCCTCCCAAA GTGCTGAAAT TACAGACATG TACCACCACA CCCAGCCCAC ACTCTACCTT 1560
CTTTTGGTTC ACAGTTCATC AGGGTTTTTC TTACCACTTC TATGAACACA TAGCCTCTGT 1620
TATGAAGTAG ATCAATTCAA ATCAGTTCTT TATGTGAATT TCCTCATTAA ATTCTATAAC 1680
CATCCTAGGA GATTGGCACT ATTATTATCC CCATTTTACA GAGGAAGAAT TTTTTTTTTT 1740
TTTAGACAGG GTCCTGCTCT GTCACCCAGG TTGGAGTGCA GTGGTGCCAT CTTGGCTCAC 1800
TGCAACACAC TCTGCCCCCT GGGGTCAAGC AATCCTCCCA CCTCAGCCTC CTGGGTAGCT 1860
GGGATTACAG GTGTGTGCCA CCACACTCGG CTAATTTTTG TATTTTTTGT AGAAATGGGG 1920
TTTTGCCATG TTACCCAGGC TGGTCTTGAA CTCCTGGACC CAAGCGATCC GCCCACCTCG 1980
GCCTCTCAAA GTGCTAGGAT TACAGATGTG AACCACCACG CCCTGTCCAC AGGGGAAGAA 2040
ATTGATGCAT GGAGAGGTCT GGTGATTTGC TCAAGGTCAC CCAGCTAGTG AGTAGCTGAG 2100
CCACAAGTCA GCCCAGGCAA TGTGGCCCCC AGAACCTAGA CTCTTAGGCA TTCTGATCCA 2160
CTGCTTCCCA CACTGCCTTC TTGAGATCTG CTGGCTCTGC TCAGGACACT GGGACAGCAA 2220
AAACACAGCC CCAGTCCTGA AGAAATCAGA GCCTTAGAGG TCAAAGTGGG AAGAGACAGT 2280
GGCAGGTCAT GTGGCTCAGG CCATTATTCA AGCAGCATTA GGTCAGGTCA CTAATCCCAC 2340
CTGGAGCAGG AAGTGGGACA GGCATCAGAT AGGGAGGCAT AGGCCCAGAG ACAGGTGGCA 2400
CATTCTGGCA CCAACACGGC AGTGATTGCA GCTGGAGCCC ACAGGAGGAT GTGATGAGGC 2460
TGGGGGTGCT GGCAGGAGCC AGATCACGGG AGCCTTGGAG CCCCTTGAGA ACCTTGGCTG 2520
TCACCTCTTA ACACAGTTTC ATGACCTCAT GCCCTGCTGG GCTGGGGCAG ATGGTCCTGA 2580
TCCACAGGCG AGAGATGGGA GAAATGCAGG GGCCAGTTTG TCAGGCATGT GGCAGAAGGG 2640
AGGTTGCTTC TTGTCTACTC TGAGCTGCTG TCTCCATCTG TCAAGTAAAA TGTGCCTGCC 2700
TTTCCAGAGT TATCGTGAGG ACTCGGCAGC AAGCCAATGG CAGGTCTCGA TGATAGTCTT 2760
TTTGCCCCTC ACATGTCACA GAGTTGCAGG TTCCCAGGGC TGTGCTGCCC ACCTCCCTTG 2820
TCCTGGATAG GATGCACAAC CCGAGTGGCT GGCTGAAGCA CAGATAGAGA ATATCTCAGC 2880
TTCTCTAGAG TCTCTTTGCC TGTCTGACAA GTTTCCAAAA GCAACTCTCA AGTCCTCCCA 2940
GGGTCCCTGG GTAGCAGAAT GATATAAAAG AGGCCAGGCT ACCTCAAAGC CAAGGCATCC 3000
ACTTTAGAAA AGCTTCCTTT GTGACTTTAA TAATTTCTTT CTGAAGGGTG GCTTTGGCCA 3060
CTCATCTCAC TACGGTTCCT GTTGCAAGGT AGCCATCTAG AATCATCCAG AAGCTTAGCT 3120
CTTCAAGCCC ACTTCAGAAA TCAGAACACA CCAATGTGCT TTGAATCTGA GCTAAAGGAA 3180
GTTACATGGT TTAGCAAGCA ATTGAGGGCT TATGTGGTTC GTTTCAAGTT TTTTGCTTGT 3240
ATCCAAAGAA CATTCCAAGC TACCCCTTTG GATTCAAAGG TTTTCTTTCT TTTTTTTTTT 3300
TTTTTTCCAC CAAGTAGACT TTTTAAAGGA GGCTGATCCT TTTTAGAAAC TCCATCCTTT 3360
ATTTTCCTTA AGGACTTGTC AAAGAGGTTC AAACAATTCT CCTGGCAAAT CATTCCTAAA 3420
TATTCATAGA TTCATCAAAG AGCTGCTAGA TTCTTGCTAT GTGCCAAATA CTGTGTTAGC 3480
CTTGGGGGTG AAGAAATGAG TGAGCACACA TCCCTGCCTT CTGGACCGCT CTTTTTACCT 3540
AGTGAGGTAA AGTTTATTAA CAAGTAAGAG AATAGCAGGT TGGGTATCAA CTCACAGTCA 3600
GAGCTCTGGA GGAAAGAAAC AGCATGCCAT AGCCAGGGGC TGAGGAGCGC TCCTCCTGCA 3660
GATAGAGTGA TCGGAAGAGC TTCTCTGCAG AGTTGACATC TGAGCTGAAA CCTGGAGCAT 3720
GAGGAGGAGC CAGGAAGGTT AAAGTGATAA AGGAGGCACT TTCCAAACAG GGAACAGCAC 3780
ACATCCAGTC CCTGAGATGC CACCAAGTGT GGCATGTTCA AGGAGCATAG TTAAGTGAGG 3840
GAGGGGCAGG AGCGCAGCTA CAGGAGAGGA TGGTGGTAGC GCTTTGCAGG CCGTGGGGAG 3900
GCATCTCACG ATAACGCCGT TTTCCCTCTT GCTTTTTTTT TTTTTTTTTT TTTTTTTTTT 3960
TTTGAGACGA GTCTCAGTCT GTCACCCATG CTGGAGTGCA GTGGCATGAT CTCGGCTCAC 4020
TGCAACCTGC TCCTCCTAGG TTCAAGTGAT TCTCCTGCCT CAGCCTCTAC AGTAGCATGA 4080
GCCACCACGT CCAGCTGATT TTTTAATTTT TTTTGTATTT TTAGTAGAGA CTGGGTTTCC 4140
CCAGTCTGTT GGCCAGGCTG CTCCCAAACT CCTGAACTCA GGTGATCCAC CTGCCTCGGC 4200
CTCCCATGGT GCTGGGATTA CAGGCGTGAG CCACCATGCC CAGCCCTCTC TTGCATTTTA 4260
AAAACCACAT CACTTATTCT TTCTTTCAAC ATAGTTGTTG AACATATTCT AGGTGTCAGG 4320
CTCTGAGTAA GATGCAAGAC AAGAATGATG AGCAAATAAT ATAAAATAAG ACCAAAACAG 4380
CAAGGGGTCC ACTGAGCCAT GCCAGCTGAG AAGGGAAATT CATGTTGAAA TGAAGGTCAC 4440
TGGAGCTGTT GGGGTCCAGT GAGAACATTG GAGCAGAACT TTGGGCTTAG GCTGGATCCA 4500
TCCCACATGT AGGGGGACCT GAGAGAAGCA GTGAAGAAGG AAAACAGTGG TGTCAGTCAG 4560
ACCAACCACG GGTCAAATCC CAACTCCAGC TGCATGAGCT TGAGCGAGCC ACTCACCCTC 4620
CCGGAACCTC AGGTCCCTCG TGGGTCTTGC CTCTCAGCTG TTGCCCAGAG TAGACGAGTG 4680
TGGCTGTGAA GTGACAAGCC CAGGGCCTGG CAGACAGTAA GTGCTCAGGA AGCATTGTCT 4740
GAACAGAGAT GGAGCAGTCT AGTATGTAAG GTGGGAAAGA AATAGGGTCT TTCATGATCT 4800
AAATCTACCA AAGCTTAATG CCAGAGAAAA GAGAGTTAGG AATAGGATTT TTTGGTGAAT 4860
ATCAAAATCC AAGTTTAAGC CACTAGCCAT CTGTATATAG TCATCTTGGA AGCGGTTATG 4920
AAACACCCAT ATTTGCACGA GGTTTTATTT GTCCCCACAT TGTTTCCCTG TTCCTTTGTA 4980
AAACCACAAG CAGTTTTTGT GTTTATCACT ATTGGCCTTG AGGAAATAGA ATATTTTGCT 5040
TTATTTTTTC GATGTGTATT ATACATTAAA GAAAATACAA TAACATCTCA TGCAGTTTCA 5100
AAAGTAAAGG GAACAGTCTT TCCCATGATT TCATCACCCT AAACAAACAA TACTTAGACA 5160
TCTTTTGTGC TCCTCCTATC TTTGTCTGTA AAAAGAGTGT ACTGTGGTCT TGCTTTCATC 5220
CCTTCTTTTT CTTTCTTTTC GTCGTAGCAC AAGAAGTTTT TCATGTTGTC ACAGTTTAAA 5280
TAAGTCTCAT TTCTTATGGC CTCATAAAGG TTCATCTGGC ATTTTCTTGC AAGTAGACAT 5340
TTTCGTTGCT TCCAGTATTA CATTATTTTC AACTAAACTA TAATGAGCAG CTTCATGAAT 5400
ACAGTGTTTT TCTTTCTTTT GAATTATTTC TTTAGGATAA GTTCCCAGAA GCGGAATTTC 5460
TGGTTCAAAG GGTATGAATG TGTTTTTTTC ATGACCCTCT GCATATTGCC AAATTGCTTT 5520
CCCGATGGGT TGTGCCCACA TTAAACTGCT TCGGCCCTCT TTTAAGAATG ACTGACTTTC 5580
ACAGCTACAT GGCCTCAGTG GGCTTCTAAC TTGAGTGACT GTCGCCTAAA CTAGGCAGCT 5640
TGCACATGCA GCAAGGAAGC AGGAGGGTGA AAACCGAGCC TTTGTTCCAG GCCAGCTCGT 5700
GGGCTCAGCA CATCACCGGT GCCATCCCGT TGTACCTGCA CGGTGGGTGC CCCATTTCCA 5760
GAACACAAGC CTGGGCTTGG GCACGTCACG TGATTACCAA GCCCCAGCTT GAGCCACAGT 5820
GTGTCTGACT ACAGAGCCAC CCACCTTCCC CTGCTCATTG GACTGATTCC CCGGTGACAT 5880
TGAGTTTGCC AGAATTTGCT TCCAGACTCA TTGAAGCAAA GAAACTGGAG CAATCTCTTT 5940
ATATTTGAGC TTGGTCAGCT GTCATCCTTT TCAAAATCTA ACCTGTTCTT CCTGGGTCAG 6000
TCCTTCCTGA TATTCTATGG AAGAATCTGA AAGAATAATA ATTTATTTTT CCTTTTTAAT 6060
AATACTTTTA AATTTGCGTC TTTATTTAGC AAAGAAAAGC GCTCAATAAA ACCCTGGGTC 6120
CCAAGCCTTA AATCTTTTGG AGGTCAAGGA GTGTGGTTGG AAGAACACAG AGCTTGGAAT 6180
CTAGTTATTC ACTAACTGAC CTTGGGCAGG CTGCCTGTCA TTGCTCAGCT TTGGTTTCCC 6240
CATCTGTAAA ATAGGAACCA TGCAGAGTCA TTAAAAGCTT AGATGAGACA ACCCCGTACA 6300
GCTGGCATAG TATGCGGCAG GCCATGGGGA ATCAAGAGAG TGCTTATTGT TTTGGGTGTG 6360
GTGGGGTGAA TTTTATGGCT CTTATGCTCA TATTTTAGCT TTCTTTTGTG AATTTACAGA 6420
GTTGTGGGGC TGCCCAATGT GCCTACCAGG CCCTTATAAC CCCCCTACCC CCATGGGAGC 6480
CCAGGTTTTG CCTCGAGTGG AGCTCCCCGC CCTGTGGGAA TCGGCCCGCC TCAGATTCAT 6540
GGACATGGCT TCTCATGTGT CCTTCCTTCT CTTAGGAGTT GGGGCAGGAA CCAGGAAAAA 6600
CATTGAGAGA TTTTATTATA CAGTCATCCC TCGGTATCCA TGGGGAATTG GTTCTAGGGC 6660
TCCCCCAAGG ATACCAAAAT CCACAGATGC TCAAGTCCCT TATATAAACG GCGTAGTGTT 6720
TGCATATAAC CTATGCACAT CCTCCTGTAG ACTTTAAATC GTCTCTAGAT TACTTATGAT 6780
ACTGAGTACA ATGTAAATGC TATGTAAATA GTTTGTTATA CTGTATTGAT TAGGGAATAA 6840
TAAGGAAAAA AGTCTGTACA AGTTGAGTAC AGATGCAACC CTTTTTTTTT TTAATATTTT 6900
TGATCTACAG TTGGTTGAAT CCACAGATAT GGAACCCATG GATACAGAGA GCTGACTGTA 6960
TGTGTATTAT ATTCTATTTT ATATTTATGA TGATGATTGT TATTATCCAT GTGTTGTTTG 7020
CAAGGCAAAA GCAGATATTG GCCTATATTG GGAGCCAAAT TCTGAACTTT TAAAGTATTT 7080
ATTGAAAGGT TACAGTTTTT CAGAGTGGTG GGCTGCAGAA AGCCACACGT TTCTGTTTTC 7140
TTACCCACCT GCTCTGGTCC TGCATGAGTT ATTTGCCTTC AAAACCCCAA GAGGAACAGG 7200
CGTTTGGGCA CAGAAATGAG CGTCTCCTTG ACTTGGACCT GGCTGTGATG GGCCGTTTCC 7260
TTTCTTTCTC ATCCTCATGG TCATGACTCC TTATTTGAGA GCTCAAGCTG CCAAATATTT 7320
CAAGTGACCA CCCACGTCTT GGGCTTTCTG TACTTGGACT GCCATGGATG TTTAAGTTTC 7380
CTGGTGCACT TGGTTAAGTG ACACACATGT CATACATTCC TGAGTTCACA CCCAGCTCAG 7440
CCACTTAGCA GGTGTGTGAG CTGAAATAAC TCTGCCCCTC TCAGCTCTGT TTCTTCCTCC 7500
ATAAAATCTT CAAGTTACAA TAAGGTGCCC ACAGTTCCTG CCACCCCGTA AGTGCTTAAA 7560
AAATAGAAGT TCTTTTGAAT TTTTTAATGG AACTACACTT CTTTTTCTCC CAATTGTTAG 7620
AGATGTCTTT ATGAAGACTG TACTTTTAAA AACTGTTGAC AATCAGATAC GAATGCTACC 7680
ACCACCATCA TCATCATTAT AACTTAAGAG CTGATCTTTC TCCAGTGCTT TCTGGTTTAC 7740
AGAGGACTGC ACTACCTTAG CATAGGGCCA GGAGATAGGA TTGCTCTTCC AGTTCCAACA 7800
TTAGGAAGTT GCTCCAAGGT CTCCCACTGG TTAGGGCGCA AGGCAGCACT GGGTGTAAGC 7860
AGGCTGACCA GCTCCTCATT GCCTGGGGTA TGAGGAGGCA GTGTGAGTGC ACCTCTTTGC 7920
AGACAGTAAT TTGGCCCCTT TCTAGTTTTG GGAGGCACAC TGCTGTATAG AGGGCACCTC 7980
CCCTCACCTA GGTCCAGACT GCAGCCTTCA GAGCCATAAA CAAGAAGACC CAAAGGCGCA 8040
CTGGGATTCG CCTTTGCAGC TCCCTAGTGG TGACAGTGGT TTGTCCCCCC AACCCCACTG 8100
TGCTGGCTGC TTTCCCTCCT GCGTTATCTC AGAACCTCCT AGCAGGCATG CGAGCTATCA 8160
TGCCCATTTT ACAGATGAGG AAAAGGAAGC TCACAGAAGT CAGGGGACTT GCCCAGCCTA 8220
GTGGAACTGG GAATCTGATG TAGACCTCAT GTGTCTGACT CTGGAGCTGT CCCCATGGGG 8280
CACTGCACCC TCAGTCAGGC CCAGCAGCTG TGCCTCAGGG AGAGAGGCCT GCAGGTGGCC 8340
TTTTCTGTGG ACTGCCCCTC TGCTTCCTTG CTCTGGTTGG TGGGCAAGCC TGTCCTGGGG 8400
CTGGAGGCTG CTTTCTGCAC ACACGGCTCC GACTGCTGGG ACTCTGCTTT GTTTCTGCTC 8460
TCTGAAAGTA CCTGGTGGCC ACACAATTCT GACCAGACAC CACTTCTATG GGCCAGGAAT 8520
CCCTGTGCTG GTGGATCCAC CTGTGCCCCT GGTCTGCTGG CAGGGAAAGC CTGAGGGGCA 8580
TTCAGGGAAC CAAGGTCACT GCCCACCTGC TAGGTGCGAG GTCTCTGCCC CGTCAGCAGC 8640
ACACCCCCTG TCGTAAGACC AAGGGAGCGG GAGTTGAAGA GACTCACCCA GGGTAGGATT 8700
TTCCTCAGGT CTCAGGCCCT GCAGCCCACA GGCATTTCAT TTCACCCTCT TCTGTCTGCC 8760
CCACCCCCGT ATTCAGTAGG TAGTACCTTG AAATGCTTTT GGAGTGATTG GGTTTTCCAG 8820
AGCCCATGCT GGTTTGGTTG GGACAGACAG ACTCAGGGTC TAGCCCTTGC TGGAAGCATG 8880
GCCTGGGCAG GTCACTTCAC CTTCTTAGGT CTCAGCTGCC CGGTCTGTGA AATGGGGCTG 8940
ACTGCTGGGC AGGGATTATT ATGAAGGTCA CCTGATACTT GGGGACAAGG TCCTGGCAGA 9000
TGACGGGTGC TCAGTTCAGG TAAAGTAACC CAAACCTGAA CCTGTGAATA ACTGAAAACA 9060
GGCTACTCCC CCTTTGATTT TTTTTTTTCT GTCTTGTTAT AAAAGCACGT ACCAGAATCA 9120
AAACACCCGA AGAGGTGGGC TTTATTGCGT TTCTTTCTTT TTTAATAGAG AGTCATGGTG 9180
TCATTTCTGG GTGTGGGGCA TCTCACTGAA ATGACTCTGC AATCTCACTC TTCTCTGCTC 9240
TCTGAACTGT 9250
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