| Tag | Content |
|---|
EnhancerAtlas ID | HS105-39127 |
Organism | Homo sapiens |
Tissue/cell | IMR90 |
Coordinate | chr19:13161640-13169290 |
SNPs | | Number: 1 | ID | Chromosome | Position | Genome Version |
|
TF binding sites/motifs | | TF | JASPAR ID | Coordinate | Motif Sequence | Strand | -Log10(p-value) |
| EWSR1-FLI1 | MA0149.1 | chr19:13168624-13168642 | CCTCCCTTCCTCCCTCCC | - | 6.88 | | EWSR1-FLI1 | MA0149.1 | chr19:13168628-13168646 | CCTTCCTCCCTCCCTCCC | - | 7.28 | | FOSL1 | MA0477.1 | chr19:13163296-13163307 | CATGAGTCACT | - | 6.14 | | FOXA1 | MA0148.4 | chr19:13168203-13168219 | CATTGTTTACTTAATT | - | 6.69 | | KLF16 | MA0741.1 | chr19:13162665-13162676 | GGGGGCGGGGC | - | 6.02 | | KLF5 | MA0599.1 | chr19:13162666-13162676 | GGGGCGGGGC | - | 6.02 | | Sox3 | MA0514.1 | chr19:13164766-13164776 | AAAACAAAGG | - | 6.02 | | ZBTB18 | MA0698.1 | chr19:13168590-13168603 | AAGCCAGATGTTG | + | 6.13 | | ZNF263 | MA0528.1 | chr19:13164394-13164415 | CCCTCCAGCCCATCCTCCATC | - | 6.01 | | ZNF263 | MA0528.1 | chr19:13165581-13165602 | TGAGGAGGGCGGGGGTAGGGG | + | 6.05 | | ZNF263 | MA0528.1 | chr19:13167846-13167867 | GGAGGAGGGCTATGAGGGGAG | + | 6.58 | | ZNF263 | MA0528.1 | chr19:13167151-13167172 | AGAGGAGGGAGTGGGGAGGGA | + | 7.01 | | ZNF263 | MA0528.1 | chr19:13166036-13166057 | CCCCCTCCCCACTCCTCCCTC | - | 7.05 | | ZNF263 | MA0528.1 | chr19:13165863-13165884 | CCTTCCTTCTCTCTCTCCCCC | - | 7.24 | | ZNF263 | MA0528.1 | chr19:13168623-13168644 | CCCTCCCTTCCTCCCTCCCTC | - | 7.5 | | ZNF263 | MA0528.1 | chr19:13166033-13166054 | TCCCCCCCTCCCCACTCCTCC | - | 7.82 | | Znf423 | MA0116.1 | chr19:13164031-13164046 | GCACCCTTGGGTGCT | - | 6.23 | | Znf423 | MA0116.1 | chr19:13167462-13167477 | GGAACCCAGGGGTGA | + | 6.79 |
|
| | Number of super-enhancer constituents: 38 | ID | Coordinate | Tissue/cell |
| SE_00024 | chr19:13160708-13176960 | Adipose_Nuclei | | SE_01540 | chr19:13160665-13178618 | Aorta | | SE_02418 | chr19:13163389-13167701 | Astrocytes | | SE_03137 | chr19:13162618-13164141 | Brain_Angular_Gyrus | | SE_03137 | chr19:13164175-13165862 | Brain_Angular_Gyrus | | SE_03137 | chr19:13166010-13168471 | Brain_Angular_Gyrus | | SE_03859 | chr19:13160698-13169369 | Brain_Anterior_Caudate | | SE_05848 | chr19:13160560-13191529 | Brain_Hippocampus_Middle | | SE_06678 | chr19:13160758-13191322 | Brain_Hippocampus_Middle_150 | | SE_07717 | chr19:13160464-13170627 | Brain_Inferior_Temporal_Lobe | | SE_08780 | chr19:13164428-13165313 | Brain_Mid_Frontal_Lobe | | SE_26006 | chr19:13163246-13168447 | Duodenum_Smooth_Muscle | | SE_26520 | chr19:13160830-13170619 | Esophagus | | SE_29770 | chr19:13161856-13170636 | Fetal_Muscle | | SE_31390 | chr19:13161511-13169318 | Gastric | | SE_33451 | chr19:13160803-13163777 | H2171 | | SE_33451 | chr19:13164746-13170600 | H2171 | | SE_35947 | chr19:13162882-13167864 | HMEC | | SE_39209 | chr19:13162670-13169330 | IMR90 | | SE_40665 | chr19:13160844-13170599 | Left_Ventricle | | SE_41557 | chr19:13160809-13169338 | LNCaP | | SE_42481 | chr19:13160839-13178550 | Lung | | SE_44148 | chr19:13162618-13168901 | NHDF-Ad | | SE_44758 | chr19:13162719-13168282 | NHLF | | SE_45899 | chr19:13162865-13168162 | Osteoblasts | | SE_46667 | chr19:13162770-13164180 | Ovary | | SE_46667 | chr19:13164208-13168405 | Ovary | | SE_46667 | chr19:13168424-13169303 | Ovary | | SE_47172 | chr19:13160769-13173616 | Panc1 | | SE_47634 | chr19:13164112-13168288 | Pancreas | | SE_47634 | chr19:13168395-13169290 | Pancreas | | SE_48143 | chr19:13160800-13169565 | Psoas_Muscle | | SE_48559 | chr19:13160842-13169380 | Right_Atrium | | SE_49775 | chr19:13164149-13168006 | Right_Ventricle | | SE_51076 | chr19:13160657-13169442 | Skeletal_Muscle | | SE_54519 | chr19:13160543-13170602 | Stomach_Smooth_Muscle | | SE_57153 | chr19:13164822-13165653 | VACO_400 | | SE_67980 | chr19:13100968-13183275 | TC32 |
|
| | Diseases: AD,Huntington,Obesity,Parkinson,Prostate cancer,Schizophrenia and Sleep disorder | | Number of disease enhancers: 1 | Chromosome | Start | End |
|
| | Number: 1 | ID | Chromosome | Start | End |
| GH19I013050 | chr19 | 13161049 | 13173134 |
|
Enhancer Sequence | GGGGAAGCTC TGGTCACAGG GGACATGCGA CCTGTCTTTT GGCTCTTTCC CTTCACTCCT 60
CTAAGCATGT GGCTGAGTAG CCTGCAGACA GATGGCCTGT CCCTTCCGTC CTTCCAGACC 120
AGCCCCCTTG GAGATGGCCC TGGGCAGGGA GAAGGCAGGC CCCAAAGCAG CCTCCAGGTC 180
CCGGGAGAAA AGCATAGTTG CTACCCTGGT GTTGTTGGTA ATGACTTGGC AGTGGAGGGA 240
GGAGGGTGCA TACCTCCAGG AGGATAGTAG CAGGGGAGCC ACGGAGTAGC TGCCCCATGG 300
CTTGGGTACT GTGCTGCAGA TCTCATCGCT GAAGGTGTGG CTAAGGCTGT CCCACCAGGT 360
GTTTGGGATG CTGTCTGGCC CCTATACCAG CCCCACTCAG GGCCAGAGGG CTCTAAATGA 420
GTCACTCAGC TCTGGCTTTG CCAGGTGGCC CAGGGTAGGG GGATGCCTCA GGTGGGCACA 480
TCACGGTGCT GCCAAAGACT CAAGGAGGAA GAGGGGTGTG TCTGGCCACT ACCCAGAGCT 540
CACTCAGGGT ACTAGGGATG GAAGGGAAGA GGAGGGGAAT GCTGTCTGAC CTGACAGCAT 600
TGCACAAGTC AGCCGTCCTG CAAGGTGGCT CTTTGCTGCT TTTCTTCTCG CTGGTTCTCC 660
CCTGTCCTTC TCTAGCTGGG ATTCCAGCTC TAGTCAGCCA GTGACATCTC CCCCGTACCC 720
AGGCCAGTGA GCCAGATTTT TTTCCAAGCC TCAAGTCAGG CAGGTTCGGG GAGGAGACAG 780
CCTCTCAGGC GAGTGAGCTC TAGAGGCCCT TCCTCGGAGA AGCCCAGCCC TCCTCCTCCT 840
CCCTTCTTGG CCCTCTCCTC TCCCTGGGCC TCTTCCCCAC GTGGCTCATT ACAACTCCAG 900
TTGTTCAGGT CTTGACCTCA AGAGCCTTCC CTATTGACCC CTGACCAGCG ATACTAATCT 960
GTGTCAACAG GCCCCAGGGG TTAAAGAAAC ACAACCCGCC GCTGCCGCCT TAGCAGGTGC 1020
CTGGAGGGGG CGGGGCGGCT CCCGGGAGCA GCCGGGCGGC TGCGGGAAGG CACTTCTTAG 1080
GCGCCGCCTC CTCCTCACAG CGCCCGCCTT CTCCGCTCCG GCTTCATGCT CTCCAGGTTT 1140
CTCCACTTCC TTTGCAGACC TCCCTCCTGC CGATTACCCA CTCCTCTGTG CCCCATTTCC 1200
CTTCTGTCTT TCCTTTGCTG TCCACTCTGC TTGCAGGATT TGGGACCAAA CGCCCTCAGG 1260
CATCCAGGTG GTGCCCGGGT TGATATGCAG CTGCCTGCCC TTGCACCTCT GGGGGCTTGT 1320
TAAAATGCAG ATCCTGGGGC TTGTCCAAGT GGGTAGGTCT GGGCAGGGCT CGTGAATCTG 1380
CATTTCCACC TAGTACCCAG GTGCTGTTGG TCCTCCAGGC TTTCCCCCTG CCTCTGCCAG 1440
CTGCTGCCTC TCTGAGATGT GCTCTTTTGT CTCCAGGAAT GGAGCCATCC TTAGGAGACA 1500
GAGGCACACT GCTGGCCATC TAGGCTGGGG GTAGAGCCCA GATGGGAGCC CACCTGGATG 1560
GCACGAACCA CCTGAGTGAT CCCCCTGTTC TCAGAACACA GGTGGGTCAC CTGAGGATGT 1620
CCTGGTGACG ATGCAGGAGC TGCCAGGCAG GACCACCATG AGTCACTGGG GGTCATGCCA 1680
GTGAGCTTCC TGCGCTGCTG GCCCTGGCTC TGCTGAGGGC CATGTCAGGG TGAAGGGGGC 1740
ACACTCCTGG CTTAGATAAG ACAATCCAGA TTCTCTCAGA GAAACAGTCA CATGTCAGAC 1800
ATGTGCCCTT TCTTGGGCTG AACCTAGAGT TGTTCATAGC CTGGCCTTAA CCCTGCCGAT 1860
TCCATATACT GTGCTCATCT CGACCCAGTT GAGGCTGTGC TTCTGTGCTT CTTGGAACGG 1920
CTCGGCTCCA GGGCCGTGAG GTTGGCACCC CCTGCACCCG TCCACACACA CAGACCAGAG 1980
GAGTGAGGAT GATGAGGACA GGGACATTAA TCACAGTTCT GTTCTGCCTG GCACTGCAGC 2040
CCAAGTCCCC AGGAGTCTGT GTCTTCCCAT GTTCCCTTCG TCCTGTTCAC AGGGAGGTGG 2100
AAATCCAGAC AGAAACCTGC CTTCTCCTCC ATCCCCACTT GAAGCTGCTG GTACTGCCTC 2160
TGGCCATCCA GCCTTAAGAC GTCCCTTCCT TCCGTGTGGC CCCACAGCCA CAGGCTGCCC 2220
CTCCTGCACA GTGCACACAT GTCTGGCAGG AGATGGCCCA GAGAAGGTGC TAAGCAGAAT 2280
GCGGGGTAGG GCTTCATCAG GGCCTGGTGT GCTGGGTGGT TTGACAGTGT TTTGTGGGGG 2340
TCTTTCCTGT AGCTCCAGGA AACCTAGATG GGGGTCAGGC TGGCTGAGGG AGCACCCTTG 2400
GGTGCTGCCC TTTTTCCGAG TGCTCTGCTT CTCTTTGACT TTACTCTCTA TCCCCTAGTC 2460
ACCCCAACCC ACTCCTTTTC CTTCTTCCTC TTGGCTGTAG CTCCCTCACA GGGCTGGGGA 2520
GCAATAGACA AACTCTCCAA AAATATTTTT TTTAAGTTTC CCAAACTTTT CCAGATGCCA 2580
AGAAGGGGCC AGGGAAACTG CAACTGCAGA GGGGGGAAGG GGAGAGGAAA TGTTCCAAGG 2640
CCTTCCCTCC CTTCCGCCTG GAGGCGAGGA TAACTATGGG AGCAGGGTGA CTCTGGTGCC 2700
CTCAGACAGT CCACCTGGAA GGGAGAAAGG CCCCTAACCA TCCCACCCTT GCTACCCTCC 2760
AGCCCATCCT CCATCCTCAT TCCCAAAGCC CCCAGCAGCA TGTAGAGGTA GAGGCAGAGA 2820
AGGATGTCAG TGGGGCACCT AGGAACTTCT GGGGTTCAGA AGGGTGGATT TGGGACATAT 2880
ACCCCCACCA GTTGAGGGAG GTCAGGAGCT GAGAAGTAGG AGAATCTGTC CCCAAGGGCT 2940
CCCTCCCTGG GAGTCTGGGG CCTGATAGAA GAACCTGCCA CTGCTGGGGT TGAGGTGTGG 3000
GGGAACAGAC AGGAGGGGGT GGTGTGTGAG GACAGTACAG GGATCACTGC CCTCCCCCAG 3060
TCCCACCCTC AAGGGGTGCT GCCCCCACCT CTACCATTCT GTCCATCCAC TCCCTGGACA 3120
CCTCCTAAAA CAAAGGCCTC TTTGTGGTCC TGGCCTACTG GCCTGCGGCC AGCGGCATTC 3180
TTTGCGTGTT TCCTGAGCAC GGATCCCAGC TTCGTGGTCA GCTCCTCCCC CACCCAGCCT 3240
GCTTCCCGGC CTGACTCCTG GTAGCTCAGA GCAGTCCCCT CTCCTGTCCT GCCCAGGGTC 3300
CTCCCCCAGT TCCCGTCTCT ACCGTGGACA GATCTGGACA GAGAAGGGAA ACTCCCAGGA 3360
GCTTGGCCAC TGGGCCTTCG GTGGGGGTTG GGGGACAAGT GGAGGTTCAA CTCCATCCCA 3420
GCTCCAGCTG ACTTTGGTGG GTTTCGCCGA GCCTCTGTTG ATATGTTCTC ATCTGTAAAG 3480
ATGGGGAAAA TAACCACCCC TTGGGGCTAT CAGGCAGATT CAATGTCTCC AAAACACAGA 3540
GCTCCTGCTT GCCGCAGAGT GGAAGAGGCA GTGTGTAACT CGAGCTCCCC ATTTCTGCAC 3600
TGCTCCCTGG GTTCCTAGGG GGCTGGAGGT GGGCTTGGTG GGCGGCTGAG GAGCTCAGAG 3660
GAGTCTCCAG AGTCTTGGGT GGGACGTTTC CCTGCACTCC TGTGGGTGCC CCAAACCTAT 3720
GGCCCACTCC TGGGAGTGCT GAGGCCAGTA CCCCAGGGAG TCCTACTCCA AGAGTCGGAG 3780
CTGGGTCCGT AGCAAGTGGC CTGCCTGTCC TAGGCCTGGT CTTGCTCTGT GTGCCCCCAG 3840
CCCCTCCTGG CATCCATGTC ACTCTGTAAC AGCAGTGGGG TGTCCTCCCT GGGTTAGGCA 3900
TACAGGGTGG TTGGTGCCTA GAGCCCTGAA AATAGCAGAC CTGAGGAGGG CGGGGGTAGG 3960
GGGACCAAGG AGGGATGGCC CAGCTTTTGG AGAACACTTT CGAATGTCAG CAGATGCACA 4020
CCCTTCAGTC ACCAGCCACA GTCACACACA GAGACACACA CAGTCCTAAT GAAGTCCTAG 4080
ATCACTGCTT TGGGGGGTTT TCCCCCCCTC TTGTTAAAAA ATGTTCATAA TTTGGAAAGA 4140
AAAGGAGCTT TTTACAAGCT GGCGGCTCTA GAGAACTTTC CGTCGGTTCT TTCTGGCCTC 4200
GTGATGGGTG GGGCCCACTT TTCCCTTCCT TCTCTCTCTC CCCCGCTCTC CTAATAATCC 4260
CCCCTTTCCA GCCTCACCAA ACACACACAC CCTTTAGGAG ACCTCCCGCC GGCTGTCACC 4320
CCAAGAAAGC TGGAGGAAAG CCGAGGACCT GTCTGTGCCC TCCTGGGCCC CATCCAAGCG 4380
CCAGGCACAA CCCTCCCCCC CTCCCCACTC CTCCCTCCCA CTTAGAGGTT GGCCCCCACA 4440
GGCCTAGAGT CTTCAGATTG CTAAGCTTCC CAGAATCTGT GCCTGGACCC AGGCCCAGCA 4500
GCCTGCCTGC CCTTCCCCGA GGGCCTGCCC CACTCTCCCG CAGGGTGAGG GTCCCCCGAG 4560
TCCTTCTTGC ATCCGGGGGC CCCGCCAGGG AGGGCAGTGC TGAGCTCACC GCCTCGGCAT 4620
CTGCCCTCCC CCTGCCTCTG GTGCGAGGGC CGGCCGCACT CCCGCCAGTG CCTTGCTCCC 4680
TAATAGCTTT TTAAGTCCAA CCACATGTGT CTGTGGAGTG AGGAGCCGCC CCTCACGGGG 4740
CCTCGGCTCT CCTCCTCCCT CAGCCAAGAC CACCCTCCAC TTGGAGCAGC CTCAGGGCTG 4800
GGGGAGGGGG GGGTCTGCCT CCTGAGAGCC CATCTGCTCG CCCCGGGCCT AGCTGAGGAA 4860
GAAGGGGGCG GGGGTCTCTT TTGGGAGTGT CGCGTGAGGC CAGCCCTCAG GCTCGGCTGG 4920
CCCCAGGTTC CCCAGCCTCT CCTCTGGGTC CTGCAGTCTA GGATCCTCTC TCTCTGTAGG 4980
GCAGGCCAGG AGGGACTGGC TTCTGGGTGT GGGAGCCTGG GTGAGGAGTC CTCATCTCAC 5040
CTCGCGCCTC CCTGGCCAGG GACTTTGGCC AGCAAATCTC TCCTTGCACC CAGCCCCACG 5100
GAGGTGACCC CCCAGTCGCC CCTCAACTCA ATATACGTGT GGTTCCCTGT GCGTGTGAGT 5160
GGTCTGTGGG GAGGCCTGTG GGGTGCGGTT TCGCAGGAGG GGAGTGAGGG CTGAAAAGCA 5220
ACGAGCTAGC AGGCTTGGGG TCCTAATGAG AAAATTGCTT CCAGCCAGGG AGCCCTGCTC 5280
TGCGGCTGAA ATTGCATCCA GCCCCAGCCA ACTTTGCTGC CGCAGTACCC GCCCTTCGGA 5340
AGGAGTTGGG GAAGCAGGCG GGCAGGGGGA GGAGCGGGCT TTGCACATGA CTCAGGCCCC 5400
CCCACCGCCC CGTTCTATAT GAACACACCT TGAAGAGTCT CTTCTGCCTC ACGGGGAGGA 5460
GCTTGAGGGT CAGGCTTGGC TCTGGACCCG ACCGTTTGAT CCTTGGGAGG CAGAGGAGGG 5520
AGTGGGGAGG GATTTCCTTT CTGTTTTGCT CAGTTCTGCT GCACTTATGA GGTGCTCACT 5580
GTGTGCAGAG GGCTTGGAGA GGTGAGCTTG CATAGGCTGG GCCCACATAG GGTGGGCCCA 5640
CCCACCCGGT GGTATTCACT CTTACTGTTA AAGGGTGTTA GGAGCACTTT GTTTTCACAA 5700
AGATCCTGCG TGGAGTCCCG CCTTCTAGGA TGCTTCATTT GAAATTCGGC CTCCCTGGAG 5760
TGGGGTGGGA CCCTCTTGCC TGTCCTTCCA CTCGGGAGCC CAGTGCCTAC ACCCGAGGCC 5820
AGGGAACCCA GGGGTGAAAA CCTGGCTTAG CTACATTCTT CTTTCTGTTC CTCACTTACT 5880
TGGACCATTG AGCAGAATCA GCTGCAGAAT TTGTGGGGCC CAGTGCAAAA TGCAAACTCA 5940
GGGCACCTTG TTCAAAAATT AAGAATTTCA AGACAGCAAC AGTGGAAGTC AAGGTTATGA 6000
AGCCAGCCCT GCTTCCAAGG AAAGCTGGTA CCACCCAGCA GCCCACTGGT TCAGGGGCTG 6060
TGGCCTTTGC CCTGATCTGA AACAGGAGGT TCCACCTGCT TGTTTCCTGG ATCCTGGGGA 6120
ATCTCTTCCC AACCTGGGAC GGTGGTCTCC CTGCTGCTGC ATCCCTCAGA GACTCTAACT 6180
TTCTGGATTT TAGAGATGTT GCTTAGGGAG GAGGGCTATG AGGGGAGGGA ACAGAATGAG 6240
AATGGATCAC ACCTTCAGTG CTTAGAGAGT CTCAGGGCAA GGCCGCACTT GTCACCCTTA 6300
GGTGAACCTG ACAGTGGAAC CATATCCCTG GTGAGGTGGA ACCTGCAGCC TGCTGGGCCC 6360
AGCCAGTAGC GGGTCAGTGG GACCTTCCCC TCCTCGGGTG GAGCCTCCCC CACCAATGAC 6420
AAGTTCTGAC GGCTGTGCCT GTGCAGAGCG GGGAGCGAGC AGGAGTGCTT GGAGGGAGGG 6480
AAGCAGGCAG GAGGAAGGAA ACAACCCCAT TGTCATCCCC CAAATTACTG GCTGGGATGG 6540
CAGGGGAGGA GGCGGAAAGC CGACATTGTT TACTTAATTA AAAGTAAACA ACAATTTGCC 6600
GCTGCCAGCC TCCCATTAGC TGTGTGCGAG GAGCCCTACG AGCTGCAGAC TCGGCTTTCG 6660
CTCCCACCAA GCCGGCTCCT GATGCCACAC CCCCAGCCTC GGCTCCCCAG GGCCCCGGGC 6720
CCTCCCCTGC TCATGTCCTC CTCAGGCTGA GGAGAGGGGA ACAAGCTATT AAAAGTAAAT 6780
AAATACATAA AAAGAAAACC CACTAGTGTC TCAGAGTCCT GTGGGTCAGG ATAAGAATGT 6840
CAGAAACTGT CATGTGGCAG GCCAGCATGG GGCCTAGAGA CCCCTGAGTG TGTACACTGA 6900
GGTCTGGTTG TGGTGGGCTG GGCAGGGCAG GGGGCACTTC TTTGTCCAGT AAGCCAGATG 6960
TTGGACTACC TGGGGAAGGC AGCCCCTCCC TTCCTCCCTC CCTCCCCGCA ACCGAGGCCC 7020
TAGTCTATAC TACCTGGAAG CCTGGGCCTC TCTGCCCCAA CTCCCACTTT TTCCTTTTCC 7080
CTTTTAGCAG CTTATAAACA TCCTTCTCCC ATCTTTTTGG CTCTGCTCCC AGAAGGGGGC 7140
TGTTCAGGGA TCCTGGAGGG CTGGGGAGAG AGGCAAGCTC CTTGGGGCCT GAGGGGAGAA 7200
AGACAGCTGG AACTGGCCCC ACCCCCAGGA CAGTACAGCT ACAAGTGACC CTAGGAACAG 7260
GGGAGGGGGT TGCCCTAAGT TGGGGTGAGG TGGGGACCCT CCCAGCTCCT GCTTCTCTGG 7320
AGCCTTCAAG CAGGAGGGGT GGTTGGATGG CAAGAGGGGT TTTGCATGGG CTTCCACCAG 7380
GCTCCAGGGG CTAAGCAGGA CACCTTTCCA GGGATCTGTC CTCAGGAAAG CCCTCACCTC 7440
TCCTGTAGGC CCTGCCTGCA ATTATGTAGA GCACAGGCTT CCATCTGGAC CTCGGTAGGC 7500
ATGACCTGAG GCCCATGACT TTAAAAGCTC AGGATGTGCG CTGGGCGCAG GAGCTCACAT 7560
CCGTAATCAA TGCCAGCACT AGGAGGCCCA GACCAGAGGG TCGCTTGAGC CCAGGGGTTC 7620
GAGACCAGCC TGGGCAACAT AGGGAGAACT 7650
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