| Tag | Content |
|---|
EnhancerAtlas ID | HS091-20435 |
Organism | Homo sapiens |
Tissue/cell | HepG2 |
Coordinate | chr17:55650500-55668880 |
SNPs | | Number: 2 | ID | Chromosome | Position | Genome Version |
|
TF binding sites/motifs | | TF | JASPAR ID | Coordinate | Motif Sequence | Strand | -Log10(p-value) |
| EN2 | MA0642.1 | chr17:55655889-55655899 | GCTAATTGGG | - | 6.02 | | ESRRB | MA0141.3 | chr17:55650591-55650602 | AATGACCTTGA | - | 6.32 | | EWSR1-FLI1 | MA0149.1 | chr17:55663739-55663757 | CCTCCCTTTCTTCCCTCC | - | 6.6 | | Esrra | MA0592.2 | chr17:55664690-55664701 | TTCAAGGTCAA | + | 6.14 | | Esrra | MA0592.2 | chr17:55650592-55650603 | ATGACCTTGAA | - | 6.62 | | Esrrg | MA0643.1 | chr17:55650592-55650602 | ATGACCTTGA | - | 6.02 | | FOSL1 | MA0477.1 | chr17:55667180-55667191 | GATGAGTCACT | - | 6.02 | | Foxo1 | MA0480.1 | chr17:55660610-55660621 | TGTAAACAGCA | - | 6.14 | | GFI1 | MA0038.2 | chr17:55666611-55666623 | TGCAGTGATTTC | - | 6.74 | | HES2 | MA0616.2 | chr17:55660970-55660980 | GGCACGTGCC | + | 6.02 | | HES2 | MA0616.2 | chr17:55660970-55660980 | GGCACGTGCC | - | 6.02 | | HSF1 | MA0486.2 | chr17:55657417-55657430 | GAATGTTCCAGAA | - | 6.67 | | JUND | MA0491.1 | chr17:55667180-55667191 | GATGAGTCACT | - | 6.32 | | KLF4 | MA0039.3 | chr17:55657808-55657819 | CCACACCCTCC | + | 6.32 | | MAFG | MA0659.1 | chr17:55654689-55654710 | GAATTGATGAGGCAGCAAGAT | + | 6.24 | | MNX1 | MA0707.1 | chr17:55654874-55654884 | TTTAATTACC | - | 6.02 | | NEUROG2 | MA0669.1 | chr17:55668701-55668711 | AACATATGTC | + | 6.02 | | Nr2f6(var.2) | MA0728.1 | chr17:55662397-55662412 | TGAACTCCTGACCTC | - | 6.22 | | OLIG2 | MA0678.1 | chr17:55664295-55664305 | ACCATATGGT | + | 6.02 | | OLIG2 | MA0678.1 | chr17:55664295-55664305 | ACCATATGGT | - | 6.02 | | POU2F2 | MA0507.1 | chr17:55661322-55661335 | TTAATTTGCATAA | + | 6.39 | | Pou2f3 | MA0627.1 | chr17:55661321-55661337 | TTTAATTTGCATAAAA | - | 8.73 | | RREB1 | MA0073.1 | chr17:55655289-55655309 | CCCCACACCACCCGCAAGCA | + | 6.5 | | RREB1 | MA0073.1 | chr17:55664907-55664927 | CCCCCACCCAACTCCCCCCA | + | 7.06 | | RUNX1 | MA0002.2 | chr17:55663190-55663201 | CTCTGTGGTTT | + | 6.14 | | SPDEF | MA0686.1 | chr17:55666488-55666499 | ACCCGGATGTA | + | 6.62 | | Six3 | MA0631.1 | chr17:55663091-55663108 | CCAGCTGATACCCCATC | - | 6.06 | | ZNF263 | MA0528.1 | chr17:55655356-55655377 | TTTCTTCCTCCCCGCTCCTCC | - | 6.14 | | ZNF263 | MA0528.1 | chr17:55656208-55656229 | TTTTCTTTTTCCCCCTCCTCT | - | 7.1 |
|
| | Number of super-enhancer constituents: 7 | ID | Coordinate | Tissue/cell |
| SE_04145 | chr17:55654096-55657071 | Brain_Anterior_Caudate | | SE_25325 | chr17:55654131-55659753 | DND41 | | SE_25325 | chr17:55659831-55669081 | DND41 | | SE_33399 | chr17:55652376-55669418 | H2171 | | SE_58611 | chr17:55657071-55716130 | Ly1 | | SE_63282 | chr17:55587959-55684078 | NCI-H82 | | SE_66871 | chr17:55652376-55669418 | H2171 |
|
| | Diseases: AD,Huntington,Obesity,Parkinson,Prostate cancer,Schizophrenia and Sleep disorder | | Number of disease enhancers: 1 | Chromosome | Start | End |
|
| | Number: 10 | ID | Chromosome | Start | End |
| GH17I057573 | chr17 | 55650568 | 55652356 | | GH17I057576 | chr17 | 55652391 | 55653150 | | GH17I057575 | chr17 | 55653251 | 55654007 | | GH17I057577 | chr17 | 55654463 | 55656315 | | GH17I057579 | chr17 | 55656623 | 55656846 | | GH17I057580 | chr17 | 55657331 | 55658362 | | GH17I057581 | chr17 | 55658598 | 55659261 | | GH17I057585 | chr17 | 55663221 | 55663370 | | GH17I057586 | chr17 | 55663521 | 55663670 | | GH17I057588 | chr17 | 55665481 | 55665630 |
|
Enhancer Sequence | TCAGTGTCTG CCCTTATTTG TCAGCATTGG TTACTAGTTA TTGTAAAGAT ATTGCCTTAC 60
ATTTATATTT CCCAAATGCA TTGATCCCTA TAATGACCTT GAAAAGCAAT AATAGCGTTA 120
TAATAATATG TAATAATAGT ATTAATGACC AGCAACTTCT GCTTATTGAT CCCTTAGGAT 180
GTGTCGTGCT CTGTGCCAAG TGCCCTCCTA CATTATCACT CATTAATAAA CCAGGTGGGG 240
AGGCTGTTAC TGGGATTTCC ATTTTTCAGA TTCATTCATT CATTTGACAA ATTTTTATTG 300
AGAATAAGTT CTAGGCACAG GGAATTCAGC AGTGAACCAC CCAGGCTGAA ATCTCTGCCC 360
TCAATGAGGA AGCTGAGCCT GTTGAGGTCA CCTGAGTTGC TCAGGGTGAT AGAGCCCATA 420
GAGTGAGGCT GGGGATCAAC CCCCATCACT CCAGACCTGC TGAGTTCCTG GGCCACCACA 480
TTTATCAGCA AGGATAACCG ACCAGCCATT GGCCTCTATT ATATGGCAGC TTATCCAGGG 540
CTGTGTTAAC ACTAAGCCTT CCATTTATTT TGGTTGATCT TCCAGGGGCT GATGGAGGAG 600
TGACAGGCTT TAGGGACAGA CAGACCTGGG CTTACATCCC AGCTCAGCGA CTCCCTGATG 660
GAAGGAGGGC ATGGACAGTG ACTTGACTTT GCTGAGCATC TGATTCCTCA TTTGTCTAAC 720
TGGGATAACA TTACTTGCCT TGAGGGCGAG GGCAGGCTAG AAGGATTAGA TATCATCATA 780
TGAAGGGGTT GAGTAGGACT TATAAGCCAA GTACGTGGTG GTGGTTGTGA CGATAATGAT 840
GACAACCTAA TAAGAAGGAA AAGCCAGGCG GGGAAAGGAA TATGGCTCAT CCTAGAGGAG 900
AACAAGTCAG GAGGTAGCTC TACCCCTCCC TCCCTGGGCT AGGATTTGTC AGTCCCAGGT 960
TGGGAAAGGA ACTCCAGCCC CTGCACATCT GTGTCTCCCC AGCCCCACCC CTCATATCCT 1020
CCATCCTAGC CCCAGCAATG CCGCTGCTCC TCTGGGGAAA GCTAATGGCC AAGGCATTAC 1080
TTAACTCCTG GCTTTTCTCC AGCCTTTGCT GAGGCCTCCA CCACTGCCAG CTTCTCTCTC 1140
GTCACTATTT GGTTATGTTC CTTTACAAGC CAATGAAATA AAATAAGAAA GTCCATTATA 1200
CCTCTGGTTG GCAGAAAACC AGGAGCTAAG AACCAGAGTG CAAAGGCCCT CATGAGTCTG 1260
TAGCACAGGC CATTGGATGG GGATGTCTTC CTTCAGAAGG ATGGTGCATG GGCGGGGCAG 1320
GGCGGAGAAG CCAGCCCATG GGCCAGTCCA CAGAGCCCAG GTCAAGGATG CAATTCTGGG 1380
TCCTGTGTCC CCATGGTTGA GCCTCTGGTG GCCACCCCCA GTCTCTCCTA GAAGGTTTCC 1440
AGCCTGGATG TGTCAGGCTG GCATGTGTGC CAGGCTGGAT GTGTCATATG GGGCACAGCC 1500
TTTAGGCGCA GCAGTAGGTG ACCCTTTGTA GGGCAAGGGT CTCTCTCTGA GTGTGGGTTC 1560
TGTCCTAGCT TTTGCCATCT ATCTTCTACC AACTACTGTG GAGCTTCGGT TTCATCAGTC 1620
TTAAGAGATG AGCAGGACAG ATGGCTCTGC CAGCCTTCAA AGACACAAAT TCTGCATTCT 1680
CTCTCTCTCT TTTTTTTTTT TTTTTTTTTG AGACGGAGTC TCGCTCTGTC GCCCAGGCTG 1740
GAGTGCAGTG GCACGATCTC AGCTCACTGC AAGCTCCGCC TCCCGGGTTC ACGCCATTCT 1800
GCTGCCTCAG CCTCCCAAGC AGCTGGGACT GCAGGTGCCC ACCACCACGC CCGGCTAATT 1860
TTTTGTGTTT TTAGTAGAGA TGGGGTTTCA CTGTGTTAGC CAGGATGGTC TCAATCTCCT 1920
GACCTCGTGA TCCGCCCACC TTGGCCTCCC AAAGTGCTGG AATTACAGGC GTGAGCCACT 1980
GTGCCCGGCC GCATTCTCTT TTTTAACTCC CTCCCCCCGC CACCCCCCGG CTGGAGCAGA 2040
TCCCTGTTCT GGCTGGTCCC ATCCCCTCCA CAAGCAGCCC ATGGACACTG AAGCTTATTC 2100
CTGGAGAGAA AGTGATTGGG AGATCCAGGG TTTTGCCTGG CTTATAGTTT CTGTGGCATC 2160
ATTTGCCCTA GATGCTCAAA CGTCCTATCT TGTCGGTGGA AGTGGCAAAA CCACATTTGA 2220
CACCGCTCTA GGTGGCGGCT CAATGGGAGT GGAGTGCTGC GCATCTCCTG TTTGACCTTT 2280
CAGTCGCTGC ATGGCTCTTC CAAGCTGCCG CAGCCTGGAG AAATGTGAAC TTTCACCAAA 2340
GCCTTTGCAA ATGAGCTTTT CCAGACAAGG CAGATGGCTT TGTTTGGCCA GGCCTGAGGA 2400
CCCCGGGATT GACTTCCTTT CTGCTCTTTC TTCTCACTGT CCTCTTACTC CCCTGCACCT 2460
CAGACCTTCA GCTAAGCAGA TTCCACTCCC CCTGGCCCAG GCTCTGGGTA GAAATTGGAA 2520
AAGGAGCCGG GCGCGGTGGC TCAGGCCTGT AATCCCAGCA CTTTGGGAGG CTGAGGCGGG 2580
TGGATCACGA GGTCAGGAGA TCGAGACCAT CCTGGCTAAC ACGGTGAAAC CCCGCCTCTA 2640
TTAAAAATAC AAAAAATTAG CCGGGCCTGG TGGCAGGCGC CTGTAGTCCC AGCTACTCGG 2700
GAGGCTGAGG CAGGAGAATG GCGTGAATCC AGGAGGCGGA GCTTGCAGTG AGCCAAGATT 2760
GTGCCACTGC ACTCCAGCCT GGGCGACAGA GCGAGACTCC GTCTCAAAAA AAAAAAAAAA 2820
AAAAAAAAAA AATTGGAAAA GGAGGCTCTG GTGGATTGAA GAAGCAGCCC TGGCGTATTT 2880
TTCTTACTTA AAACTTGGTC TGGGACTAAC TGCCTCTGGT CAGAACTGAT TTAGTTTTTA 2940
GGAATCATTT GTAAGACAGA CACTGTGGGA AGGCCATCCT TTAAAGCCAT TGATTCCTGT 3000
AATAATTATT TGCTGAACAC TGGCTCTGTG CTGGGCACTT ATCAGGGGCT GAGGATATGG 3060
TGGTGAACAA AACCAACAGC AGTCCTGGAG CTCAGGCTCA ACAACTCTAT TCCTTGCACA 3120
CATTCTAGCC GTGGAGAATG TGGGTTGTGT GCTTCTCACA GCCTTGAAGG CAAGGGCTGG 3180
ATCCTACTCT CCATTGTATC CTAAAGGCCC AGCTGAGATT CTTTCATATA GAAGGTATCC 3240
AATGAATGTT TGTTGTAGGA ATAGATGTTT TCTGTATTTC CTAAGACTCT AAAATGAATG 3300
TTACTTTTAT AATCAGAAGA CCATAATCCA TGTTGGCTGG GTGCAGTGGC CCACACTTGT 3360
AATCCCAGCA CTTTGGGAGG CCGAGGCAGG TGGATCACCT GAGGTCAGGC GTTTGAGACC 3420
ACCCTGGCCA ATATGGTAAA ACCCTGTCTC TACTAAAAAT ACAAACATTA GTGGCACGGT 3480
GGTGCATGCC TGTAATCCCA GCTACTTGGG AGTCTGAGGC ACAAGAATCG CTTGAAACTT 3540
GGAGGTGGAG GTTACAGTGA GCTGAGATGC GCCACTGCCC TCCAGCCTGG GTGACAGAGC 3600
GAGAATCTGT CTTTAAAAAA AAAAAAAAAA AAATGACTAT AATCGATGTC TAATTTTAAA 3660
GAAAAAAAAA AAGGAAGGTT GGGCAGGGCG AGATTTTGAC ATGGTTTATA GGAAGCCTGG 3720
GGTTTTTTTA GTTGACTGTT AAGTTTTCTT TGAGGCAACA GGTGATGGAG CTGCTAAGGA 3780
CGCCACCACA AAGGGAAGTC CAGTCCGGTA TTTGGTTGCA CTGCTCAGAC CCCATGTGGA 3840
ATATTCCATT CCAGGCATTT ATTTTAAGAG GGGCATTGAC AAGATAGACC ACATCAGAGG 3900
AGGTCGTCTG ATGGGGACCA GGACAGTATT ACGGGAAAAA TTCCAGAGGA ACCAAGGAGA 3960
CTCGAATAAG GAGAAATGAG GTGGCTACGT TAGATCTTGA AGGACTACCC CTGGGAGGGG 4020
GGCCAGGCTG CTTCCCCAAC CATGAGTGGC CGTTTGTGAA GTTACCAAGA GAAAGGCTGA 4080
TCCTTGGGCT GAAGAATTTA GCAACACCTC AAGATGCCCA ACTCAAACAA GCTGTGTTTA 4140
TGAAGTACCG AGGGGTGATG CCCCTTTCCC CAGAAATATT CAGAGACTAG AATTGATGAG 4200
GCAGCAAGAT GGGGCCAGGG ACCACTTTGC AAACCACTGG TGGGTCCTGC ATTATGAAAG 4260
TCCAGCCTGG TCCAAACCGT CCCATTTCCA GACCCATAGA GCCCAACTGG TAATATTTCA 4320
GGAGGATTCT GTATAAAATT ATATCTTTAA GCCCTGGTCT CCAGTAGATA TTGGTTTAAT 4380
TACCAGTTAT TTACTGCCAT GCTCAGTAGA TGATAGACAA GCAAGAGAAA AGGATAAAAT 4440
GAAAAAAATT AAAAAGAAAA TTCCAAACCC TTTGAGGTAG TAGGAAGAGC CCCCTACTTG 4500
CTGAAGATGA TTAAGAAATA AAGAGAAAGC TTTTCTTGGA GTCATGATGT AAGCCCAAAG 4560
GGAAAGTAGG TTCTTATTTA TGAAAAAAGG TTATAACTTA AGCTGTTCAG AAGCACAGCA 4620
ATTACTTGGA GTAAGATGCC TCTTAATTCA TTTGGCCTCC TTTGTAGGTG GCTGAGTAAG 4680
TGTTTCTGCG TCCTCGGACT CCAGCCCTTC TTTGGTCGCC ACTTGCTTTT GTTCACGGCA 4740
GGTCACTGGG TACTCCAGAG GCATTGTTGA TAATAACATC TCTTTCCTCC CCCACACCAC 4800
CCGCAAGCAA AGCTTTGGAA AAACAGCCAA GTGTTCAGCA AAGTGAAGGC TTCGCTTTTC 4860
TTCCTCCCCG CTCCTCCCCT TGTTGAGAAA TCCCATTATC CGGGAGAATG ATTGTGAAAC 4920
TCCAATCTGT CTGCCGCTGA GCTGTGGGCC GTTCTTCTTG CCTCCTCCGC CCCTGCCCTG 4980
GTCCCCTTGT CTATCTGCAG GGGGAAGACA AATATCTATA TATTAAAGCT TTAAGAATCT 5040
ATAAATCTGA GTTGATTCTC TGCTGGTGAC AGCCCAAGCT CTTTCCCACC ACGTTTGACA 5100
TGATCTAATG GGTTTACAGT TGTTTGAGTG CTTCTCTGAA GCAAATGAAA GTGCTTAGTT 5160
AGGGGACGTA TGAAATGGCA TTGTTTGTTC TGGGCACTAC AGCAAAGCTA GGGGATCATC 5220
TTTAAATTAT CCACCCTTTC TCTTCAGCCA CCCCGCAGAA CAAGGGGCTC TGCCGCTGAA 5280
GGAGCTGCAA AGACAGTTCC TACTGGCCTT GCCTTTCTGC TTGAGAGGTG CCAGGACTGG 5340
GGGGGTAGGA TGCATCCCCA GCTGTATTCA TTTCGCCAGG AAGCTTGGGG CTAATTGGGA 5400
ACAGAAGAAT GCCCAGGGGA TGAGGGGAAG GGGACGGGAG AAGGATGGTC TCACCAAGGT 5460
AGAGGAGTGA CAAATACTTG CTTCTAGCAA AACAGGAGTA AAAACAAGAG AGACTCCTAA 5520
TGAGAGCTTT GGGGCAGTTT GTGCTTTCCA TTCTCAGGGG CCAGCAGTGT GGGTTGGTGT 5580
GATTAGTTGC CTTGCTACTT GGCGCAAAAC CAATTCCTCT TTTCAATATC AAGTTTCATA 5640
AGCGTGGAAC AGTAACAAAT CATTATAAAC CCTCTGGGAC TGGTGGGTGT GTGATGATGC 5700
GGGGTTGTTT TTCTTTTTCC CCCTCCTCTT TGATAAGCCC ATCTTTTCAG CCCAGGTACA 5760
TTTTTCCCAT TGTAAACAGA AAATGGCATG GGAGGGAGTG TGTCTCGGAA ACTTGCTGTA 5820
TTGTTAATCT GTTATTAGGC AAAAGTCTTA ACACCAGGCT GGGTGCTCAG ATGCCTCATT 5880
GTGAGCTGGG GATGGAATTA TGCATCATGA ATAAAAACCG CTGTCAACAT GCATTGGTTT 5940
CAAAACATTA GAGCATATGG TATGTGATTA TCTGTATTGT CAAGTGCAAT AAAGTGAATT 6000
TGGATATAAT AAAGGATGTA ATATTTTAGA AATTTGGTAA TAAACTAAGG AAAGGATGAC 6060
AGCTGAGGTT CCTTAAGGCC CCAGACACAA ATAAATTGAA GTTACTGGTC TCTGTGGCCA 6120
AGTGGCAGAA TGGCCGTAAC ATGGCTATCT GTGCTCGGTG ATTTTCAAGT TGGGGAAAGC 6180
TCTGCTGTCG CTCGGTTGCC TTCTCTGGAG GACGCAGGGA TGATCTGGCC CCCATGCTGG 6240
GTGGTGGGAG AGGCGGTGGC TCCCGTTGGA GACCCAGGTC TTGCCTCCTT GCCTGGCCTC 6300
AAGGTGTGCC CTGTGGCCTG CTCTGAGTGG CAGACGCATC TGCCTCCAGT CAAGGGCCGC 6360
CTTGTGCCAG CCATCAGGAC ATCTGAGGAC CCCTCTCCCC TAGACAGTCA CCTCTCAGTT 6420
AATCTCCAGC CCTCTTTGTC CCCATTTGGT CAATGGGAAG ATGTTGCTGT AAACGCAAGG 6480
ACCCTGAGCA GCCGCCCCTT GGAGGCAGCC GTCTTCTGGA ACCCACATCC TACAGGGCCA 6540
AATTATTAAG TCATGACAGC AAGTCAATAT AAGTAATGAG AATGGTCCTC TAGAGAGGCG 6600
TGAGTGCTTC AGCATCTGAT GGGGGCTAGG AACTGTGCCA GGCTTCGGTG TACTCTCTCC 6660
TTAAATCCTC TATAACCCTA TAATGCTGCT GTCCCTATTT GAAGGATGAG AAAGCTGAGA 6720
CACAGCCAAT CAGTTGTGGA ACAGAGATTA CAACCCATGT CTGAACCCAA AGCCCAGGCT 6780
CCTTCCACTT ACAACCTTTT CTACAAATCC AGAGGCTCTT TCCATTCATA GTCCACAAAT 6840
AATAACCCAC ATGTTCAGAA GGCCTCACCA CAGGAAACTG GAAACCTTTA CATTACTGGG 6900
TACCTAGGGC CTTGAAAGAA TGTTCCAGAA AAAAAAAAAA AATAGAACCA GGTGACCAGC 6960
TGTCTCCTCT CTGTTCCCAC TTGGGCCTAG CAGGGGCTGA TCTGCCTTCA TTATTCCTGG 7020
GGTTTTCCCT TAGCACTGAT TTTTCTGTCC AGCTCTAGCA GGGTGAACCC ATTTATCATC 7080
ATATCCTAAC AGTTTGCCTT GGTTCAGAAC TCATCTTCCT CCTCTGGGAA GGGCTCCTGC 7140
CCCCACCAAA CCAAAGTTTA TCGATGAAGG CTGAGGCAGC ATCTGTTTGC ATCTCCTGAC 7200
TGACTGCTTT TGTGTTTCTG ACCCTGGCTT TACCTTGACC CCTGGCATTT GACTTCAGGG 7260
CTTGCCTTGG CCCCCAGCCT ACAGGAAACC CCGGGTGAGG CCTGCCCCCC ACACCCTCCA 7320
CTTAGGCCTG GCCCCTTCCT TCCACCCCGG CATTCTGTGG CTCTTCCAGT CCTGGCTTCC 7380
AGTGCTGGTC TTGCTAGCTG CCCTGCCAGG TGGACGGCTT CATTAGTAAG CGTGAAAAAT 7440
TGGGAGTGCC ACCATCAGGC CAGGCTAAAG CAATTTGGAT GGCTGGGAAA AGAGAAGACA 7500
TTTAGTCCAT TTCATGCCTG GATACCCCTG TAATTCCTGG GACAGGCTGG GAAGAGGCTT 7560
CAATAAACCC CTCTGGCCTA GGAATCTTGT GACCAGTTTG CACTGGAGAC GACAACTAGG 7620
TGAGTTCAAA TACACTTCCA AATCGCTCAG CTTTGGTACC TCAGAGGTGG CTCTGCTAAA 7680
GCTCTTATCA CCGCAGTCAA CATTTATTGA TAGCTAAAGT ATTTTCAAGT CTCAGCTGGT 7740
AGCCCACTCA TTCCAAGCAA TATTGGGTAT AAAATCTTTA TATAAAAACA ACAGACTTGT 7800
GCAGGCATAA CCAGAACTAG CATTATCTCA TTTAATCCCC ATGCCAGCCC CATGAGGTCA 7860
GCATCTTTTT TTTTTTTTTT TTTTTTTTTT TGAGACACAG TCTCGCTTTG TCACCCAGGC 7920
TGGAGTGCAG TGGCACGATC TCTGCTCACT GCAACCTCCA CCTCCCAGGT TCAAGCGATT 7980
CTCCTGCCTC AGCCTCCCAA GTAGCTGGAA CTACAGGCGT GTGCCACCAC GCCTGGCTAA 8040
TTTTTGTATT TTTAGTAGAG ATGGGGTTTC ACCATGTTGG CCAGGCTGGT CTTGAACTCC 8100
TGGCCTCAGG TGATTCCCCA GCCTCCACTT CCCAAAGTTC TGGGATTACA GGTGTGAGCC 8160
ACTGCACCCA GCTGAAGTCA GCATCTTTAT TCCTACTTTA TAGGTGGGGA CATAGGATCA 8220
GGGAGGTTGA TGGCTTGCCC CACATCACAC AGCTAGTAAA CAACCAGGAT TTCTACGATG 8280
TCCTCGGATC CAAGATTCAA ATCCTCCCAG TCCATGGAAT TTCACTCATC TGTCTTAAAA 8340
GAGTGTGTTG CTTTCTCCTC CTCCCCACCC AAACCCTTCC ATGTAGGTTC TTTTGAGTAG 8400
GCTACACTGA GTGACATCTG AGAACAATTT TCTTTAGGAA AAAGAGACCT TGAGTCGCTG 8460
TCTCGTGAGT TTCTCCCAGA CACAGTCTTA GAACATGTAG AGGGGCTGAG GGTGAACCCC 8520
GAAGAACACT TGTGTTCTTG CTCCAGATCC CCAGGGCTGC CCACTGACAA CTGTCCCCAC 8580
CCTGCTGAAG AGCTGGTGAA ATTGAACCAA ATGCTCCTAA TGATCTGTGA ATGTATTAAT 8640
CCTACTTTCT GTTAATTAAC AATATGATAA AACCAGCATT TCGTAAGTCG TCGCTTAACA 8700
CATGTTTTAG CAATTATATA CTTAGTGGTT TGTATTCAGA ATGCTAATAG AATAAAATTT 8760
TAATGAAGAT ACGATGCTAT GAAAAATTTA TTGAGACGAG TTCAGGTATG GCTGCCGTTA 8820
ACATGCAGGA GACAAGCATC TCAGTTTGAA GAGTGAACCT CCCCAATGCC TCTCAGCACT 8880
GTGTGCTGCT CAGTCAGGAG GACCCAGGAG ATCCTGAAAT TGGCTGATTC TTGACTCCCG 8940
TGAATTTCTC ATGCAAAGAT CCCTTCTTGG TGTGGGGAGG GGTCCACACC CGCTGGCAGT 9000
CACTGAAGGT CCCTGTTCCC ACCCTACCTC CAGACTTCTA GCAATCTCTG TGAATAAGAG 9060
GCAACTTCAG AACCAGAGTC CATGATGTAC CATCTCACCT TCTCCTAGAG AGTCTCCAAA 9120
ATTTTTTAAT TGTGCAGAAA AAAAAATTAG CATGCCGCCC CCCAATATAT CTTACCTGAT 9180
TTTTAATTTA TATGCATGTA CCGCTATGTT AATATTCATG TATATTATAA AACCTATACA 9240
AATAGGACTA TAATAGGATA CATTAAGAAT TTTATTTATT AATAATTAAA GTAATATTTT 9300
TATTACTTTA GAGAGCAATA TGATTGAATA TGCTGGTTTT AAAAAAGAAT TCTTGATTTA 9360
ACACTTCATG ATCCAACTCT AAAGGTTGGA TTCTAAGTTT AGTTTATTTT GATACTTGGT 9420
TTTAATGCCT GGCATAACTG AAAAATACAC CTCACAAGAT AAACAGATCC CAGCGGAGGA 9480
AGCACGATTC ACTGTGCTGG CTAAATCATG ATACTAATTT TTCAACCCCA TCCTCCAATT 9540
ATGCAAAGGA TTTTGTTGAA ATTCAGCTTG TAAATTTCCA TCTTCCCTGA TGTCAATCAG 9600
TTTTTCATGC AAACTAATCA AGTGTTGCAT TTTTATATTT TTAACAAATG GGTTCAAAAT 9660
CCACTGAAAT GTTCATGTTT TTTTTCAAAT GAATCTTTAC AGTTCTGTTT CCGGATTTTA 9720
AAAGTCTGCA GATATGAGAG CTTTTGTAGA TGACCTAGTT ACATCATTTT TAGCAACAAA 9780
AACACTAAAC AATAGAAATA TTTTCCAAAC ATTTGTTTTC AAAGCACTTT CTCTACGGTA 9840
CCAGTTTCTG TTGAAAATCA GGTTCTTCCT CATTCACTTG GCTGCAACTT GTCCCATCTG 9900
ATCAAGATAT GTTTTTGGGG GTGTGATGTG GCTGGTTAGG TGTCTTGCCT AAGGGTATGG 9960
AAAGGGTTGG CTGACCATTT ACTTTTGTGG CATGTGCTTG TATCATTAGT ATTATCTCCA 10020
ATCCATGTTT TCTTTGCAGT TACCTACTTT GTAAGGGTTG GTTTTCTTAA AGCCAGATCG 10080
CATAATCTAT ACCTCCATTT ACTGGTTACC TGTAAACAGC ACAAGGTACC AGCTGTGCTC 10140
AGGTGAGTAA ATGAGGAGCC CCACCCTCAT GGAAACATTT CCTCTTTTCC TTTAGTGGCT 10200
TATAAGGACA AGTGTCTTGC TGACATAAGG ACATGTGAAG GCACTGGGAT TATTCAGTCA 10260
TATGATAAAT GTTAGTGAAG CTGGAATTAT TTCCAGGTGA CAAAAATTAG GCATTAGGCA 10320
TTATACTTTT TTCCTTCTCC CAATGTTTCT TTTTTTTTTT TTTTTTTTGA GACAGGGTCT 10380
CACTCTGTTG TCCAGGCCGC AGTGGCATGA TCTTAGCTTA CTGCAGCCTT GACCTCCTGA 10440
GCTCAAGCTT CCCAAGTAGC TGAGACCACA GGCACGTGCC ACGACGTCAG GCTAATTTAT 10500
TTTATTTCAT TTTTTGTAGA GATGTGGTTT CACTGTGTTC CCCAGGCTGG TCTCAAACTT 10560
CTGAGCTAGA GCAATCTGCC TGCCTTGGCC TCCCAAAGTG CTGGGATCAC AGACATGAGC 10620
CACCAAACCC AACCTCCCAA AGTTTCTTAA CCCTAACTGA ATCACTTGGG AGATTTTAAA 10680
ACATACAGAT GCTGGGGTGC TACCCCTAAC TCAATTCTGA GGATGGGACC TGGACATCAG 10740
CATTTTGAAA TTTTTCCCTG AGTGGCTCTG ATGTAAGACT CACTACTGAG AAGCAGTGTT 10800
CTAGACTGAT GCATCTTACA TTTTAATTTG CATAAAATCA CCTGTTAAAA TGCAGATTCA 10860
GGTTCAGTGG GTCCAGGGTG GGGCCTGAGA CTGCATTTCC AACCAGCTCC CTGGTGGTGT 10920
GGATGTGCTG ATTGGTAGAA CACCCTAAAT AATGAGCTCC AGACTGTGCT GCCCCCTGTC 10980
CGCAGTAGCC TCCTCACCTC ATTCCTCCCT GTCACTATCC CAGGCCTTTG CTGAAGAGTC 11040
AGGGAGCAGT CTCCGCTCCC TCCTGGCAGA GCCGCCACGC CAATCCAGCT GCCTGGGCTG 11100
CTGGTCACAG CTTCTCAGAG AAATCTGGCT TCCAGATGTT AAGAACAGTT CCTTAACAGC 11160
TGGAAGAATA TAATAAAATA GGCCAGACCC CACCCCCTGG TGAATTTAAG TATGTGTGTC 11220
TCTTGCAAAC CACTCATCAG AGGCACCCGA TGGTCATCTG CCTGCCCGCA GACTCCAGGC 11280
AGGTTTGCTG GCAGTGTAGC CGGGTGGGGT CATGGAGATG CTGGCAGGAA TGACCCCCCT 11340
GTGGGGGGCG CGGAGGGAGC AGTGGGCACC CAGCCAGGGC TCTGTCAGTG GGACTGGTCT 11400
GAAACCATAC CTCATAATAA AAGTCATATA ATTTGTGGCA GCGCTGAAAA CCTGCTCCAA 11460
GTAGTGGTTT CTTGATGGAG TTTTGGAACC TTATCTGCGG CTGGTAACCA TTCCTTGAGA 11520
ACTTGTTGGA GAAAGGCGAG TGAGCATCTT AAGAAGGCTG CTGGGGAAGC TGAGTGCACC 11580
AGGGCGGGGG GCCAGCATGC CCGCACCCTG CACAGCCAGG TGCGACACTC AAAGATTAAT 11640
GGATGATTTG GGTTTTTTTT TTTTTTTAAC CTAAATGGAT GCACCTTAGG GTCTTTTTTT 11700
GAGTTGGGGT CTCGCTCTGT CACCCAGGCT AGAATGCATT GGCATGATCG CGGCTCACTG 11760
CAACCTTCGC CTCCCAGGTT AAAGTGATTC TACTCAGCCT CCTGAGTAGC TGGGATTACA 11820
GTCATGCGCC ACCACTCCTG GCTCGTTTTT GTATTTTTAG TAGAGACGGG GTTTCACCAT 11880
GTTGGCCAGG CTGGTCTTGA ACTCCTGACC TCAAGTGATC CACCTGTCTT GGCCTCCCAA 11940
AGTGCTAGGA TTACAAGCAT GAGCCACCAC CACGCCCAGC CCTCTTAGGG TCTTTTAAAA 12000
GTAACAAGGT GACCTAGGAA TTCACTGCAT GACTTGTTTT ACCTCTCCCT GTCCTGAATC 12060
TTATCCCATC ATGATAGTTG GTAAAGCACC ATGAACATCT GCCTTACAGA CATGTCAAGT 12120
GGATTTTAAC AAGTGAGGCT ATATACAGAG ACAAAAGTAA GCATGTGTGG AGATAGAGAT 12180
TGGGCTAGGG GAGAAATAAC AAGGCTAGTT TGACTGATAG GAGGGGCTAG CTATCTTCTC 12240
AGAAGTGCAG GTGTTTTTAA GCAATCCTGA CTGGTGAGGT GGATCATTTG TCTCACAGAG 12300
GAGGATACCA AGGGTCAGAG TGGTTGAATA ACCTGCTCAG AGTCATGCAG CCAGTTGTGC 12360
TAGAGCCAGG ATTTAAGCCC AGATCTACCC AGCTCCAAAG TCTAAGCCCT TTTCCACCCA 12420
CCTCAGTGGG GACATTAAGT AGATTGAAAC TCCCTCTTAG CTTGTGTGTT GCTCGCTGCA 12480
TGGATGAGGC TGGAGGATGA ACGTGAGAGA AGGTGACAAA TTTGAAACCC ACTCTTCAGT 12540
GGAGTAGCTG GGGGTACCAA CCCAAAAACC CACCTCCAGA GGGAAGAACT TCCAGCTGAT 12600
ACCCCATCTC CCCTGAGCTC AGAAAGCCCT GAGTTGAGAA TCCTTGAAGG CCATGCTCCC 12660
GCAGTTGGAG CTCGCCAAAG CCGCCCCGGG CTCTGTGGTT TCCAGAGCAG ATGCGGAGGC 12720
GGCACGTCCT CGTGCCCTTG CTCCAGCTGC GCACACGACC TCAGCCTCCT CTGCCCCGCT 12780
GGGCGCGAGC TGCAGTCCTG GCACCTTCTG CTGGGGTCCT GATCTGAGCC AGTTGTCTAG 12840
CGATTTAATT TGGTGAATTT ACCACTGCGT CCCAGAGTTT ATATTGGCAC TTAACAGCAG 12900
TAATATGTTT CTCTCTCGCC AAGAACTATT TTCCCGACCA AGATGGAACA CCACGCACAA 12960
AAAATAGGTT TGTGAACTAA TCTGCTGCCC TGACAAGTGT CATTCACAGA ATCACTGCTA 13020
TAGAGCGCAC TCGGAATTAA ATGAGGCTGG GGTTGTCTGG CCTGGATCAC AGGTGCTTTT 13080
TCCCACTCAG TTAACAGGAG TCTGGGATGA GACACCCTTT CCCTGCAGCC GCAGGCACTT 13140
TCAAATCACA CTATCAGTAT TCATGACAGA TTTCTCTCTT AGAAAAATGG TTTGAGGATG 13200
GTTAGAGGTC TCTCTCTCTC TCTCTCTTTT CCCTTCTAAC CTCCCTTTCT TCCCTCCTGG 13260
GTGGTTCTTT TTAGGATGCC CCCACCCTGT CTGTCCTTAT AAAATGCAGC TCTGTAAACA 13320
TTTGTCTAAT TTCACAAGCT CAGGGAGGTG CCCCCATCAG TTAAAAAAAA AAAAATCTCC 13380
TAGTGCCTGA TGCCTGTTTG AAATTCTAAA GTGGAACTTA ATTGCTTTCG CGTAAGGATT 13440
TGATTCGGGC AAACTGCCCA TACCTCTGGG AGTAGAAGCA GGATCTGTCA TTTACACTTT 13500
AGTCTGAATG GGTGCCTGAA CCTGGGAGAA AACAGCTTTG TCTTTCCCTG GTCTGCCTTG 13560
GATGTCAGAG GCTTCTTAAA GACAGCGTTA TTGAGGGGCA TGGTGGCTCA TACCTGTGAT 13620
CCCACCCCTT GGGGAGGCCA AAATGGGAGG ATCACTTGAG GCCAGGAGTT CGAGAGCAGC 13680
CTGGCCAACG TGGCAAAACC CCATCTCCTT AAAAAAAAAA AAAAAAAGTT TCCCACTTCA 13740
TGTAAGAGAG TTCCTCAAAA TTCTCTTTCC TGTGGAGAGT TCTAGATTCT CTTTTACCAT 13800
ATGGTCTCCA CTTAGCTTGT CTTGAATTGG GAAGCATAGG GCAGAGTCAG GCTTGCGTCA 13860
GCATCAGAAT TACCAGAGAC CTGGGTAAAA ACGCAGTTCC TGGGCAACAC CCACTGAGAC 13920
CATGTTAGGA GCTGGCAGAG CCCAGGGATC TGCATTTTTG ACAAGCCCTT CCCCCATGAG 13980
AGATTCTGCT GCAGGACCAT ACCCAGAAGC ATTGGTCTAG GAGCACACTT GGCCCTCAGC 14040
CCCACCTTGA TATATTGTCT AGGAGCATCC ATAAATAAAT GGTCGCCAGG TTATGGTGGC 14100
CAATTGGAAA AACTCTTTGT AACTAAAGCC TGATGAAACA CTTGCTGGTT CATGGTTGGC 14160
GCCTGACTTT TAGAAGGTTT CTCCTCACAT TTCAAGGTCA AGGGTTGGCC AGCGCATCCC 14220
TGAGCTGAAA AGGAAAGAAG AGCACCTTTC CAGTTGAGAA ATTGGCTCCC CTCTGGCAAA 14280
TGCCGCCAAC GTAGCTTAAT ATTAATTTAG GGAATGCAGT CTTGTGCAGT TCCATGGAAC 14340
TAGATTGGAA ATCTGATAGT GCCATTTCTG TTATCTGATT CCTCACACAC CTGAGATCAC 14400
TCCCCGCCCC CCACCCAACT CCCCCCAGCC CCAAAGGTGG CTGCAGAGGC GCAGGTGTGA 14460
GCTGGCTCAC TAAGTCGCTT TCCCCCTCCT GATTAAGCGT GTGGGGGAAT AAAGAAGACC 14520
CGTGTCGACT CACGCCGATC TCTGCCTTGC CTGTGCTTGA GCCACTTGTA ATTCCCCACA 14580
GCCCCAGCCA GGTCTGCAAG GCAGGAAGAA ATATGACCAG GCAAGTTGAG AAAATAAATT 14640
AAACTAAGTG TCAACTTTTC TTGTTTCTCT CCTCATTATT AAGAGATGGA ATGGGGCTCG 14700
TTTATCAAGC AGGGGGAGAA ATTAATTGAC ACGGCTTTAA TATCATGATG TCTGGCGTGT 14760
CTGGTCACAT TCCTTCATTT TCTGGAAAGG CATTTTATTA TAGTTTACAG CAACCAGCTG 14820
CCAAACTACT GGTGTAAACG AGGAAGCAGG TGCATGAAGG ATGCCACAGT GGAGGGGCTG 14880
CGATGCCACC CTAGAGGGGA CGGAGACATG GCAGAGAAGG AGGGCCAGTT CAGAAGGGAC 14940
CCCAAAGAGA GGCTGCTTAT TTTGGGGGGA GGGAGGAAGA AGGATATCAG GGAGGAGGGA 15000
GGGCTGTGCT AAGAGGGCAT GCCAGCAGAC CCCTCGCATC CATCGCGGGC TTGTTTACTG 15060
GCCCACCAGG AGGGCAGTCT CAAGTATCTG CCTCTGATGG CCTCCTGACC TGGAAGTCTT 15120
TGTTCTTAAC CATCCCTGAG GCTGGGTGCT GTGTACAGCT CAGGTCAGCG TGCCTGCCCC 15180
TTTTCTTTCT TCTTAATAAG GCCAGGGAAG TGAGCACTTC TCTGTCCCTC CCTCCAGGGC 15240
AGCTGACTCA TTTGAGAGCC AGTTTGCTGC AAAGAAACTT CTAGCATCAA GTCTGGCATC 15300
CCAGTCCTAC TTCAGGTACA TCTGCGGTTG GGGGTCTGGA AAGGTTCGGA GAAGTCACTC 15360
TGCTGTGCTC ATCCTGGTTA GACTGGCTTA GGAGATACTC TAGCTGTTTT TCTGTGTGAA 15420
GGTCTTCTTT GCTGTGTATC TCTGAAAATC CTCAGTGCCT CCTTCCCTGC TCTTATATTT 15480
AAGAAATCAC ATACTTCAGG GTGCAGGGGA AGCCAACATA GAGCTGGAGT GGATGACCAT 15540
ATCTTTCCCC ACTCTCTCCT TGCCCTCTGT CTGCCGGATT GTAAGAACTG AGGGCTCTTG 15600
CCTATTTCAT AGATGTTCTT ACAGGGAAAC ATGACAGAGA CAGGGTTCAG GGGTGCAGTT 15660
GTTGGACAAG GTAGGAATTG ATGAGTATGG AACAGTCTGC CTTCATATGA AGAAGGTGGG 15720
CTGCAGGGGA GAGAACACAG GGTCCCACTG GGGCCTCAGT TCTTCGTCTG TGAAGTGGGA 15780
ACAATCATTT CTATTCATAC TCCCCAGGGT GGGGCTGGGG GTGAAGATTG AGTTACAGAG 15840
TGGCTGCTCA GTGACGGCAG ATGAGCTTTC TCTTTTTAAC ATTATTATTA GAATGTGGAC 15900
TGATCCTCAA TAACCACCTT TGGGAAGCAG ATGCGAGTTG TAATGGAAGG AATCCTAGCC 15960
CTTCCCACCT TACAAAGTCC ACATTGGCAC CCGGATGTAA AAGCACACAC AGCCTGATCA 16020
TCACCCACCC TTTCCCAATC CCTAGTGTCT GAAAACGCCC AGGAACCTCT AATGGCGACT 16080
CCAATTGGCT CTCACTGAAG CCAAAGTATT GTGCAGTGAT TTCCCAACAT GGCAGCCAGT 16140
AATCAGAAAC ATGCTGCTGC TTTTGAAAAG GTAGCTTGTT TTTTTTCTTG GAACATACTG 16200
ATCTTCTGAG TTATATTTTT CTTAGAGCAA AGCCAAGGCA TGTGATGCCA CCTCCCCATG 16260
CCTGCCATGC ATCTGTGCAC ACTACTCATC GCTTCTGCAC TTCCAGGTGG GGCCTCAGAC 16320
CTTCCAAGTT TAGGGTTGCA GGACAGCTGA CTTGCCAAAC CTGCCATAGC TCATGGAGGT 16380
GACCTAGAAA CGTTCCGCGT TGGGGCTGGG GACAGCCCGA GGTGTGGGGT TGCCAATGGA 16440
CGCACAGCCA ACTGGGGCTC GACTTGTGAC GATGCAAGCA CACCACCATG CCTCCTTGCC 16500
AGGCCGGTCC CTCTCATGCT CTCTGAGCCA TATGGCCACC AAATCCATCC CTGAACACTT 16560
ACTGATCCAA AGAAGACCCT GACAGTCTTC TCCAGAAAAG TAGGGGGGAG TGTGAAAGTA 16620
ACTTGGGGTA CCACTCCTGG GTTCAGTTCC TGCCTCTGGT TTAGCGGCCA TGTCACGATG 16680
GATGAGTCAC TGAACTGTGC AGAGCACTTG AGCACAATGA CAGTAGCAGA GCCTGCCCTG 16740
CCTCTCGCAG AGTTGCCTTG GGGACCAGGT AGGACGATGG ATGAAAAGGA TTTTCAAACC 16800
AGAAAGTGCT CCCCACACCC ACACCCAAGG GATTCATTTG TGCTGGAAGC AACCCATGAA 16860
TATTGCTTTC CCCAAATACT AGGTTATTAG CAAGAGAGGG AAGCTGCATG AGTTATAAAT 16920
ATTCTTAAGT ACACATACCT TAAATTTCTC ATGGGATACC CAGAATAAAT TTGACAATCT 16980
GGGGTTTTTT CCTCCCTCAT TTTTTTTTCT CCATTAACCA AGTATGTTAA CTCATGACTT 17040
GCATTGATTT TCACTGAAGA TGCATTAGAT ACTACATGAT TGCCCATTAG TGTTCATTGA 17100
CCTATATGAT AAGAGAAGAA AATTATTTTT GAGGCTAGGA GGAGGCTGTT CCCATCTTTC 17160
TCTCTCTGAC CTAAAAAAAA ATTCTCTTGT AAGTTAACTG TCGATGTTCC TCAGTGACTG 17220
CGTTTGGAGC AGGTCATTTT AATTTTGAGG TATCTCGTTT TCAGATTTCG ATCTTCTTCT 17280
TCTGTGTATG TGGTCTTTTG TAGCTTTTAT TATTCAGATG AATATTTAGT TTTGTTCATT 17340
TGGATAAAAG AGGGGGAAAA GGTTTGACTG TTAAATGCTT ATCTCTTAAA TAGTGCTTAC 17400
TTGTTAGTTT CTAATAATAG CTTCATTCAA GAGAATGCCA GAATTTCATT TTTAAATGCT 17460
CCCTGTCAAC TGCTACCCTA TTAATATCCA TTTTTAAACC ACTGGTGTTT AGGGTTAACC 17520
TTCCCACCAC CTTCTTTGTC CCCGCTTTGC TGACTACTGG AGCCCCTTGG AAGTGTGGGG 17580
TGCAGTTAAG GTGGGGGCTT TAGGAGAGGC GGGGCAGGTG CCACTTTGCT GATGCCAGGT 17640
GAGAAGGGTT TCTTTGGTGA ACTAGTCTCT TGTTGCCCAA GTTCTGGCCC TTTGTTTCTC 17700
CCACCTCCCC TAGTTGTCAG TCCCTGGGTC TCCTCTCCAT CCTGGGTGGT GGCTTGAGTG 17760
AGTTTAAATA CCCAGGGAGG AGTTCTCTGG TTCTTAGGAC CAAGGGAGAT GAGCAGTGGA 17820
TGTTCACAGG GGTAACCCAG AGGGCCCCGA TGGAGTGCCA GCCCTCACAG ACTCGCCATA 17880
GACTAGAATC CTCACTCTGT CAGGGCCTGG AGCAGGATCC CTGCTTCTGC CTGCATCTCT 17940
TACAGGTCCA GAGAGGCAAA GGGAGTCTCT GGGGCACATA GCTTGTTATC TGGCCCCTTG 18000
CTGAGTGAGG ATAATTGTGT GTCTCTTTTA CCTGGCTGCT ACACCTCAGT TTGATGGGCC 18060
TTCATGAGGC TCCATTTCTG ATTCTCTGTG GGGCCCTCTT CTAGGGCAAT GAGAAGGAAA 18120
TAATCATGAC TCCCTGTCCT CCATCTCTCC CAAATCTCTT GTACATCCAG TAGATTGTTC 18180
AAAAGACTAT GATGCCTTAA AAACATATGT CAAATAAAAC AAGCCAGGCA CAACAGTACA 18240
GGACATAGAG TGTATGATGC CACTTATATG AGAAAATTCA TAGTCATAAC AAGTAAAATA 18300
TAAGCCGGTG TGGTGGCTCA TGCCTGTAAT CCCAACACTT TGGGAGGCTG AGGCAGGAGG 18360
ATCGCTTGAG CCCAGGAGTT 18380
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