EnhancerAtlas 2.0: an updated resource with typical enhancer annotation in 600 tissue/cell types across nine species

EnhancerAtlas 2.0

Tag

Content

EnhancerAtlas ID

HS091-09967

Organism

Homo sapiens

Tissue/cell

HepG2

Coordinate

chr12:53497990-53498890

Target genes

Number: 27
Name	Ensembl ID

RPL7P41	ENSG00000241146
KRT18	ENSG00000111057
KRT8	ENSG00000170421
AC107016.1	ENSG00000225410
EIF4B	ENSG00000063046
RP11	ENSG00000257475
TENC1	ENSG00000111077
SPRYD3	ENSG00000167778
IGFBP6	ENSG00000167779
SOAT2	ENSG00000167780
VTI1BP3	ENSG00000258074
HIGD1AP1	ENSG00000258016
ZNF740	ENSG00000139651
CSAD	ENSG00000139631
ITGB7	ENSG00000139626
RARG	ENSG00000172819
MFSD5	ENSG00000182544
ESPL1	ENSG00000135476
PFDN5	ENSG00000123349
C12orf10	ENSG00000139637
AAAS	ENSG00000094914
SP1	ENSG00000185591
PRR13	ENSG00000205352
PCBP2	ENSG00000197111
MAP3K12	ENSG00000139625
TARBP2	ENSG00000139546
NPFF	ENSG00000139574

TF binding sites/motifs

Number: 8

JASPAR ID

Coordinate

Motif Sequence

Strand

-Log10(p-value)

GLIS1	MA0735.1	chr12:53498757-53498773	TGACCCCCCAGGTTGT	+	6.13
NR2C2	MA0504.1	chr12:53497995-53498010	GGATGTCAGAGGTCA	+	6.34
NR2C2	MA0504.1	chr12:53498002-53498017	AGAGGTCAGAGGTCA	+	8.73
NR2F1	MA0017.2	chr12:53498008-53498021	CAGAGGTCAAGTG	+	6.62
Nr2f6(var.2)	MA0728.1	chr12:53498276-53498291	TGAACTCCTGACCTC	-	6.22
Nr2f6	MA0677.1	chr12:53498003-53498017	GAGGTCAGAGGTCA	+	7.42
Rxra	MA0512.2	chr12:53498003-53498017	GAGGTCAGAGGTCA	+	6.88
Zfx	MA0146.2	chr12:53498301-53498315	CCCGCCTCGGCCTC	+	6.01

HEDD

Diseases: AD,Huntington,Obesity,Parkinson,Prostate cancer,Schizophrenia and Sleep disorder
Number of disease enhancers: 1
Chromosome	Start	End

chr12

53498703

53498791

Enhancer Sequence

GTGAGGGATG TCAGAGGTCA GAGGTCAAGT GGACAGATCC TTGGTAGCAG GAAGCAGGAG 60
TGAGGCTTGG TGATAAAGAT GACTTTTTTT TTTTTTTTTT TTTGAAACAA AGTCTCGCTC 120
TGTTGCTCAG GCTGGAGTGC ATTGGCACAA TCTCGGCTCA CTGCAACCTC TGCCTCCCAG 180
GTTCAAGCGA GTAGCTGAAC TACAGATGAG TGCCACCAGG TGTGGCTAAT TTTTTTTTTA 240
TATTTTTAGT AGAGACGGGG TTTCACCATA TTGGCCAGGC TGGTCTTGAA CTCCTGACCT 300
CAAGTGATCT ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGTGTG AGCCACGGTG 360
CCCAGCCTGA TGACTTGTTC CTGAGTGCAA AGATCGGATT CGAATTAAGG ATGGAGATGG 420
AGGGGTTTGA AGCACAGGTC CCAAAGGTCA CCAAAAGTCA GCCAGTAGAT AGAGTCTTCC 480
TGCTAGTGCG GCTGGAGGCC AGGGGTGAGG AGTGACAATC GGAGGTGACC AGGCTGGAAT 540
TCAGACCCAG GGAGGGGAAG CCTTGCTCCT GCTGTCACTC CCTGATCCTC GCTGCTGCCC 600
CAGGAAGCCA GAAGGAGATC AACTCTGGGC AGGGATCATG GCTTGTTCAT CTTTTTACCA 660
CAGCACTTAG CACTGCGGGG TCCTACCCCA CCAGCAGACC CATCACCACC CCACCAATGC 720
CTGCCCTTCC CCCCGCAGGC CTGCCACCAC TGAACCCCCA TCCCTGCTGA CCCCCCAGGT 780
TGTTTTTTTT TTTAAAAAAA GCACTGTGCC TGGCATAGAC AGAAATTCAG TGAATGTCTG 840
GTGAATGAAA GGATGGCTGA CTGGAGGGAC AGTGGGCTCT ACCCTGGCTT TGTCCCGTAG 900